Immune and non-immune functions of the immunoproteasome
Immune and non-immune functions of the immunoproteasome
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DOI：
10.2741/4027
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Luo, Honglin
中科院分区：
文献类型：
--
作者：
Angeles, Arkhjamil;Fung, Gabriel;Luo, Honglin
泛素-蛋白酶体系统在控制无数细胞过程中的生物学重要性已得到公认;然而，免疫蛋白酶体（蛋白酶体的诱导形式）的病理生理学意义直到最近才得到很好的理解。最初认为免疫蛋白酶体的主要功能是改善MHC-I抗原呈递。免疫蛋白酶体具有更广泛的生物学功能。它调节促炎细胞因子的产生以及T细胞分化和增殖。除了免疫功能，免疫蛋白酶体已被证明可以通过氧化损伤蛋白的有效周转和减少有害蛋白质聚集体的形成来缓解氧化应激。此外，它还涉及调节肿瘤细胞生长和控制肌肉质量。最后，免疫蛋白酶体最近作为癌症和自身免疫性疾病的潜在新治疗靶点引起了相当大的关注。本文综述了免疫蛋白酶体的结构和功能，强调了其在免疫和非免疫反应中的功能多样性，并讨论了免疫蛋白酶体的失调与几种人类疾病的发展之间的关系。（字数：174）
The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately. The primary function of the immunoproteasome was originally believed to improve MHC-I antigen presentation. It now becomes evident that the immunoproteasome possesses broader biological functions. It regulates proinflammatory cytokine production, and T cell differentiation and proliferation. Alongside immune functions, the immunoproteasome has been demonstrated to relieve oxidative stress by the efficient turnover of oxidatively-damaged proteins and by allaying the formation of harmful protein aggregates. Furthermore, it has been implicated to regulate tumor cell growth and control muscle mass. Finally, the immunoproteasome has recently drawn considerable attention as a potential novel therapeutic target for cancer and autoimmune disease. This review will give an overview of the structure and function of the immunoproteasome, highlight its functional diversity in both immune and non-immune responses, and discuss the relationship between the dysregulation of the immunoproteasome and the development of several human diseases. (Words: 174)