IRON ACCUMULATION IN HUMAN CHRONIC RENAL-DISEASE
IRON ACCUMULATION IN HUMAN CHRONIC RENAL-DISEASE
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DOI：
10.1016/s0272-6386(12)70222-6
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发表时间：
1992-12-01
影响因子：
13.2
通讯作者：
HARRIS, DCH
中科院分区：
文献类型：
--
作者：
NANKIVELL, BJ;BOADLE, RA;HARRIS, DCH
在肾脏疾病的蛋白尿模型中，铁已被证明在近端小管溶酶体中积累，可能通过产生活性氧在慢性肾脏疾病的进展中发挥作用。因此，对蛋白尿和/或慢性肾衰竭患者进行肾活检，通过能量弥散分析在超微结构水平上检查铁，并与正常活检进行比较。铁在肾病患者近端小管溶酶体中积聚（P< 0.05），部分患者伴有磷和硅。肾病综合征患者（n = 12）的含铁溶酶体数量（1.86±0.41）和溶酶体铁平均浓度（254.5±73.4 mg/dLv81.2±23.8，P< 0.001）均高于无肾病综合征患者（n = 8）。铁积累（含铁溶酶体/小管数量）与蛋白质排泄相关（r= 0.68，P= 0.003, n = 20），但与肾小球滤过率无关。损伤小管的铁含量高于损伤小管（288.5±68.5 mg/dLv80.4±13.9，P< 0.01）。需要进一步的研究来确定铁在引起肾小管损伤和肾脏疾病进展中的可能作用。
Iron, which has been shown to accumulate within proximal tubule lysosomes in proteinuric models of renal disease, may play a role in the progression of chronic renal disease by the generation of reactive oxygen species. Therefore, renal biopsies from humans with proteinuria and/or chronic renal failure were examined at an ultrastructural level for iron by energy dispersive analysis and compared with normal biopsies. Iron accumulated in proximal tubular lysosomes in renal disease (P< 0.05vnormals), accompanied in some cases by phosphorus and silicon. Both the number of iron-containing lysosomes per tubular cross-section (1.86 ± 0.41v0.66 ± 0.22,P< 0.05) and the mean concentration of lysosomal iron (254.5 ± 73.4 mg/dLv81.2 ± 23.8,P< 0.001) was greater in patients with nephrotic syndrome (n = 12) than in those without (n = 8). Iron accumulation (number of iron-containing lysosomes/tubule) correlated with protein excretion (r= 0.68,P= 0.003, n = 20), but not with glomerular filtration rate. Damaged tubules contained greater amounts of iron than tubules with less damage (288.5 ± 68.5 mg/dLv80.4 ± 13.9,P< 0.01). Further studies are needed to define the possible role of iron in causing tubular damage and progression of renal disease.