Daily versus standard hemodialysis: one year experience.
Daily versus standard hemodialysis: one year experience.
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每日血液透析与标准血液透析：一年经验。
DOI：
10.1046/j.1525-1594.1998.06213.x
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发表时间：
1998
影响因子：
2.4
通讯作者：
W. Arkouche
中科院分区：
文献类型：
--
作者：
J. Traeger;Roula Sibai;E. Delawari;W. Arkouche
本研究的目的是比较4例标准血液透析患者的临床和生物学结果，这些患者最初接受每周3次4-5小时的治疗，并在一年内转换为每周6次，每次2-2.5小时的每日血液透析。模式和每周总透析时间保持不变。每日血液透析组血压和左室重量指数明显下降（P < 0.01）。观察到尿素时间平均偏差（Kt）显著降低（p < 0.005），Kt/V指数显著增加（p < 0.05）。随着热量摄入从33+/-3.21增加到40.8+/-6.35千卡/千克/天（p < 0.05），干重增加，标准化蛋白质分解代谢率（nPCR）显著增加（p < 0.0038）。一名正在接受促红细胞生成素（EPO）治疗贫血的患者可以停止治疗。未观察到动静脉瘘并发症。每日血液透析似乎是治疗尿毒症患者高血压和左心室肥厚的首选方法。由于透析频率增加，尿素氮增加至接近健康肾脏的值，这可能是临床改善的主要原因。
The aim of this study was to compare clinical and biological results in 4 standard hemodialyzed patients originally treated by three 4-5 h sessions per week and converted within one year to daily hemodialysis sessions of 2-2.5 h each 6 times per week. The modalities and the total weekly dialysis times remained the same. With daily hemodialysis, the blood pressure and left ventricular mass index decreased significantly (p < 0.01). A significant decrease in the urea time averaged deviation (TAD) (p < 0.005) and increase in the Kt/V index (p < 0.05) were observed. A gain in dry weight was shown with a rise in caloric intake from 33+/-3.21 to 40.8+/-6.35 kcal/kg/day (p < 0.05), and the normalized protein catabolic rate (nPCR) increased significantly (p < 0.0038). One patient who was receiving erythropoietin (EPO) for anemia could stop his treatment. No arteriovenous fistula complications were observed. Daily hemodialysis seems to be the method of choice to manage hypertension and left ventricular hypertrophy in uremic patients. The increase of the urea TAD to a value closer to that of the healthy kidney due to the increase of the frequency of dialysis is probably the main explanation for clinical improvement.