Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer.
Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer.
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DOI：
10.1054/bjoc.2000.1658
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发表时间：
2001-03-02
影响因子：
8.8
通讯作者：
Costa A
中科院分区：
文献类型：
--
作者：
Paradiso A;Simone G;Lena MD;Leone B;Vallejo C;Lacava J;Dellapasqua S;Daidone MG;Costa A
对84例接受甲氨蝶呤和氟尿嘧啶/亚叶酸钙联合化疗的复发或转移性结直肠癌患者进行了bax和bcl2蛋白表达的临床相关性研究。Bax和bcl2胞浆免疫染色阳性率分别为65.5%和38%。未发现bax和bcl2之间或p53与bax和bcl2蛋白表达之间的相关性。此外，生物标记物与患者和肿瘤特征无关，已知这些特征会影响结直肠癌患者的临床结果。总体而言，与细胞凋亡相关的标记物似乎不能指示短期和长期的临床反应，也不能预测预后。Bcl2阴性病变在达到客观临床反应的患者中更常见，这与之前报道的关于其他肿瘤类型的数据一致。当研究P53和Bax表达之间的相互关系时，发现P53和Bax不表达的肿瘤患者的有效率(40%)较好，而P53阳性和Bax阴性的肿瘤患者的预后较好(2年总生存概率为75%)。在目前接受全身化疗的晚期结直肠癌患者中，我们没有发现凋亡相关标记物的表达与临床结果之间的明显关联，甚至在TUNEL法检测细胞凋亡指数的患者中也没有发现明显的相关性。©2001癌症研究活动http://www.bjcancer.com
The clinical relevance of bax and bcl-2 protein expression has been investigated in 84 patients with recurrent or metastatic colorectal cancer submitted to a chemotherapy regimen including methotrexate and fluorouracil/leucovorin. Cytoplasmic immunostaining of bax and bcl-2 was present in 65.5% and 38%, respectively, of the tumours. No association was found between bax and bcl-2 or between p53 and bax or bcl-2 protein expression. Moreover, the biomarkers were unrelated to patient and tumour characteristics known to affect the clinical outcome of colorectal cancer patients. In general, the apoptosis-related markers did not appear indicative of short- and long-term clinical response nor of prognosis. Bcl-2-negative lesions were more frequent among patients who reached an objective clinical response, which is in agreement with previously reported data regarding other tumour types. When the interrelationship between p53 and bax expression was examined, a better response rate (40%) was found for patients whose tumours did not express p53 and bax, and a better prognosis (2-year probability of overall survival 75%) for patients with p53-positive and bax-negative tumours. In the present series of patients with advanced colorectal cancer submitted to systemic chemotherapy we did not find a clear association between expression of apoptosis-related markers and clinical outcome, even in the subset of patients in which the apoptotic index as determined by the TUNEL approach was investigated. © 2001 Cancer Research Campaign http://www.bjcancer.com
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DOI：
10.1083/jcb.119.3.493
发表时间：
1992-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gavrieli Y;Sherman Y;Ben-Sasson SA
通讯作者：
Ben-Sasson SA
影响因子：
15.9
作者：
Bargou, RC;Wagener, C;Dorken, B
通讯作者：
Dorken, B
影响因子：
45.3
作者：
Apolinario, RM;vanderValk, P;Giaccone, G
通讯作者：
Giaccone, G
影响因子：
8
作者：
Abdel-Rahman, WM;Georgiades, IB;Wyllie, AH
通讯作者：
Wyllie, AH
影响因子：
45.3
作者：
Costa, A;Doci, R;Silvestrini, R
通讯作者：
Silvestrini, R