NICOTINE MAINTAINS ROBUST SELF-ADMINISTRATION IN RATS ON A LIMITED-ACCESS SCHEDULE
NICOTINE MAINTAINS ROBUST SELF-ADMINISTRATION IN RATS ON A LIMITED-ACCESS SCHEDULE
复制标题
DOI：
10.1007/bf00589894
复制
发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
COEN, KM
中科院分区：
文献类型：
--
作者：
CORRIGALL, WA;COEN, KM
静脉注射尼古丁在药物强化水平上保持了实质性反应，并采用有限进入、固定比例5的自我给药方案。反应证明了预期的药理学敏感性，尼古丁或美加明治疗前剂量依赖性降低，但六甲双铵治疗后未降低。此外，反应取决于单位剂量的大小，最大值出现在0.01和0.03 mg/kg/输注时。在高于和低于这些剂量时，自我给药行为都会减少，并且在用生理盐水替代尼古丁后消退。在0.03 mg/kg/输注剂量下，总疗程药物摄入量随单位剂量增加，最高达约0.5 mg/kg，但在0.06 mg/kg/输注剂量下未进一步增加。0.03 mg/kg/输注剂量下的超时持续时间缩短也未改变尼古丁的总摄入量。这表明尼古丁摄入量受获得的药物总量和单位剂量的大小的控制。这些结果表明，静脉内尼古丁可在啮齿动物中维持大量的自我给药行为。
Intravenous nicotine maintained substantial responding on the drug-reinforced lever with a limited-access, fixed-ratio 5 schedule of self-administration. Responding demonstrated the expected pharmacological sensitivity, it was dose-dependently reduced by pre-session treatment with either nicotine or mecamylamine but not with hexamethonium. In addition, responding was dependent on the size of the unit dose, with maximum values occurring at 0.01 and 0.03 mg/kg/infusion. Self-administration behavior decreased at doses both above and below these, and extinction followed the substitution of saline for nicotine. Total session drug intake increased with unit dose up to a maximal value of approximately 0.5 mg/kg at 0.03 mg/kg/infusion but did not increase further at the 0.06 mg/kg/infusion dose. A decrease in the time-out duration at the dose of 0.03 mg/kg/infusion also did not change the total session intake of nicotine. It is suggested that nicotine intake is controlled both by the total amount of drug obtained and by the magnitude of the unit dose. These results demonstrate that intravenous nicotine can maintain substantial self-administration behavior in rodents.