Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration
Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration
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DOI：
10.1016/s0021-9290(03)00246-x
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发表时间：
2004-02-01
影响因子：
2.4
通讯作者：
Steffen, T
中科院分区：
文献类型：
--
作者：
Baroud, G;Falk, R;Steffen, T
利用丙烯酸聚合物渗透多孔骨结构是一种新兴的骨质疏松性椎骨增强手术。虽然这种方法经常被采用，但它是基于经验知识进行的，因此，没有考虑到人类椎体松质骨的孔隙率依赖的渗透性。本研究的目的是：(a)从实验和理论上研究椎体松质骨通透性和孔隙度的相互依赖性，以及(b)检查脊柱松质骨的骨通透性是否可以通过骨矿物质密度测量来预测。如果能够建立这些关系，它们将有助于优化注入条件，以预测水泥入渗。为了确定孔隙度依赖性和定向渗透性，从20个腰椎中取出34个骨芯，其中20个在上下（SI）方向，14个在前后（AP）方向，并用粘度与PMMA相匹配的硅油浸润。根据达西定律确定岩心的渗透率。SI和AP岩心的平均渗透率分别为4.45 +/- 1.72 × 10（-8）和3.44 +/- 1.26 × 10(-8) m(2)。本研究的一个有趣发现是，尽管取自同一椎体的SI和AP岩心的孔隙度大致相等，但AP岩心的渗透率约为SI岩心的78%。此外，我们还提供了一个理论模型，该模型准确地描述了骨通透性和孔隙度在两个方向上的非线性依赖关系。虽然骨通透性与孔隙度的关系已经建立，但骨矿物质密度是骨通透性的弱预测因子。本研究的实验和理论结果可用于理解水泥渗透过程中的聚合物流动。(C) 2003 Elsevier Ltd.版权所有。
The use of acrylic polymers in infiltrating the porous bone structure is an emerging procedure for the augmentation of osteoporotic vertebrae. Although this procedure is employed frequently, it is performed based on empirical knowledge, and therefore, does not take into consideration the porosity-dependent permeability of human vertebral cancellous bone. The purpose of this study was to: (a) experimentally and theoretically investigate interdependence of the vertebral cancellous bone permeability and porosity, and (b) examine if the bone permeability of spinal cancellous bone can be predicted using bone mineral density measurements. If these relations can be established, they can be useful in optimizing the injection conditions for predicable cement infiltration. To determine the porosity-dependent and directional permeability, 34 bone cores-20 samples in the superior-inferior (SI) direction and 14 in the anterior-posterior (AP) direction-were cut from 20 lumbar vertebrae and infiltrated with silicone oil with a viscosity matching that of PMMA. The permeability of the cores was determined based on Darcy's law. The mean permeability of SI and AP cores was 4.45 +/- 1.72 x 10(-8) and 3.44 +/- 1.26 x 10(-8) m(2), respectively. An interesting finding of this study was that the permeability of the AP cores was approximately 78% of that of SI cores, though the porosity of the SI and AP cores taken from the same vertebra was approximately equal. In addition, we provided a theoretical model for the porosity-dependent permeability that accurately described non-linear dependency of the bone permeability and porosity in both directions. Although the relation of the bone permeability and porosity was established, bone mineral density was a weak predictor of the bone permeability. The experimental and theoretical results of this study can be used to understand polymer flow in cement infiltration procedures. (C) 2003 Elsevier Ltd. All rights reserved.