Localization of function within the dorsal hippocampus: The role of the CA3 subregion in paired-associate learning
Localization of function within the dorsal hippocampus: The role of the CA3 subregion in paired-associate learning
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DOI：
10.1037/0735-7044.117.6.1385
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Kesner, RP
中科院分区：
文献类型：
--
作者：
Gilbert, PE;Kesner, RP
计算模型和电生理学数据表明，海马 CA3 分区支持任意关联的形成；然而，尚未进行任何行为研究来检验这一假设。对神经毒素诱发的背齿状回 (DG)、CA3 或 CA1 损伤的大鼠进行了物体-位置和气味-位置配对联想任务测试，以测试支持配对联想学习的机制是否局限于背海马的 CA3 亚区，或者是否所有海马亚区都有助于配对联想学习。数据表明，患有 DG 或 CA1 损伤的大鼠能够像对照一样学习任务；然而，CA3 损伤的大鼠在学习任务方面受到损害。因此，背侧海马的 CA3 亚区包含支持配对联想学习的机制。
Computational models and electrophysiological data suggest that the CA3 subregion of the hippocampus supports the formation of arbitrary associations; however, no behavioral studies have been conducted to test this hypothesis. Rats with neurotoxin-induced lesions of dorsal dentate gyrus (DG), CA3, or CA1 were tested on object-place and odor-place paired-associate tasks to test whether the mechanism that supports paired-associate learning is localized to the CA3 subregion of the dorsal hippocampus or whether all hippocampal subregions contribute to paired-associate learning. The data indicate that rats with DG or CA1 lesions learned the tasks as well as controls; however, CA3-lesioned rats were impaired in learning the tasks. Thus, the CA3 subregion of the dorsal hippocampus contains a mechanism to support paired-associate learning.