Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.
Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.
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DOI：
10.1016/j.jep.2006.11.038
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发表时间：
2007-05-04
影响因子：
5.4
通讯作者：
Reutrakul, Vichai
中科院分区：
文献类型：
--
作者：
Panthong, Ampai;Norkaew, Pinpaka;Reutrakul, Vichai
在泰国民间医学中，藤黄是一种由藤黄分泌的黄色胶质树脂，用于治疗感染的伤口、疼痛和水肿。通过实验动物模型评估了藤黄乙酸乙酯提取物（GH5763）的抗炎、镇痛和解热活性。结果表明，GH5763对大鼠急性期炎症有抑制作用，如苯丙酸乙酯诱导的大鼠耳水肿和卡拉胶诱导的大鼠后足水肿。然而，GH5763对花生四烯酸诱导的后足水肿没有任何抑制作用。在亚慢性炎症模型中，GH5763对棉球诱导的肉芽肿模型均能显著减少转行期和增殖期。GH5763还能降低该动物模型大鼠血清碱性磷酸酶活性。在镇痛试验中，GH5763对醋酸诱导的扭体反应和福尔马林试验的早期和晚期均有抑制作用。此外，在酵母诱导的高温大鼠实验中，GH5763也具有良好的解热作用。推测GH5763的抗炎、镇痛和解热作用是由抑制前列腺素的生物合成引起的。(c)爱思唯尔爱尔兰有限公司2007年出版
In Thai floklore medic ne, gamboge, the yellow gum-resin secreted from Garcinia hanburyi, is used for infected wound, pain and edema The ethyl acetate extract from Garcinia hanburyi (GH5763) was assessed for anti-inflammatory, analgesic and antipyretic activities using experimental animal models. It was found that GH5763 possessed inhibitory activity on acute phase of inflammation as seen in ethyl phenylpropiolate-induced ear edema and carrageenni-induced hind paw edema in rats. However, GH5763 did not elicit any inhibitory effect on arachidonic acid-induced hind paw edema. In subcronic inflammatory model, GH5763 provoked a significant reduction of both transudative and proliferative phase when tested on cotton pellet-induced granuloma model. GH5763 also reduced the alkaline phosphatase activity in serum of rats in this animal model. In the analgesic test, GH5763 elicited inhibitory activity on acetic acid-induced writhing response and on both the early and the late phase of formalin test. Moreover, GH5763 also possessed an excellent antipyretic effect when tested in yeast-induced hyperthermic rats. It is postulated that the anti-inflammatory, analgesic and antipyretic activities of GH5763 are caused by the inhibition of the prostaglandin biosynthesis. (c) 2007 Published by Elsevier Ireland Ltd.