Determination of water concentration in brain tissue by Raman spectroscopy
Determination of water concentration in brain tissue by Raman spectroscopy
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DOI：
10.1021/ac0101306
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发表时间：
2001-08-15
影响因子：
7.4
通讯作者：
Puppels, GJ
中科院分区：
文献类型：
--
作者：
Wolthuis, R;van Aken, M;Puppels, GJ
脑水肿是颅内肿瘤和脑血管病变患者最常见的致病因素之一。监测颅内压只能间接地、全面地衡量脑肿胀程度。我们已经评估了拉曼光谱作为评估脑水肿的替代方法的适用性，该方法直接测量组织中的水浓度。根据在2600-3800-cm(-1)区域测量的拉曼光谱，建立了偏最小二乘模型，预测脑组织含水率在0.75-0.95范围内，精度优于0.01。
Brain edema is one of the most common morbidity factors in patients with intracranial neoplasms and cerebrovascular pathology. Monitoring of intracranial pressure gives only an indirect and global measure of brain swelling. We have made an assessment of the applicability of Raman spectroscopy as an alternative method for assessing brain edema, which measures the water concentration in the tissue directly. Partial least-squares models were developed on the basis of Raman spectra measured in the 2600-3800-cm(-1) region, which predict the water fraction of brain tissue in the 0.75-0.95 range, with an accuracy better than 0.01.