Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease
Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease
复制标题
基于网络的统计显示阿尔茨海默病的功能连接异常
DOI：
10.1109/jstsp.2016.2600298
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发表时间：
2016-08
影响因子：
7.5
通讯作者：
Liu Yong
中科院分区：
文献类型：
--
作者：
Zhan Yangfeng;Yao Hongxiaong;Wang Pan;Zhou Bo;Zhang Zengqiang;Guo Yan'e;An Ningyu;Ma Jianhua;Zhang Xi;Liu Yong
Alzheimer's disease (AD) and mild cognitive impairment (MCI) have been associated with impaired communication among large-scale brain networks. Given nature that interconnected subnetworks are responsible for daily behavior than a single pair of functional connectivity, it is valid to use a network-based statistic (NBS) method to exploit the clustering structure of connectivity alterations in AD/MCI. We explored abnormal network components using NBS based on resting-state functional magnetic resonance imaging (fMRI)connectivity in a sample of patients with AD (N = 35), MCI (N = 27) and age-matched healthy subjects (N = 27). The results demonstrated that patients had reduced functional connectivity strength in several components, including the default mode network, sensorimotor network, visual-sensory network, and visual-attention network. In patients with AD, the functional connectivity of these components of interest (COIs) exhibited greater attenuation than that in MCI subjects compared with normal cognition. A greater degree of cognitive impairment was correlated with a greater decrease in functional connectivity in the identified COIs. These results indicate that the neurodegenerative disruption of fMRI connectivity is widely distributed in several networks in AD/MCI. These profiles deepen our understanding of the neural basis of AD/MCI dysfunction and indicate the potential of resting-state fMRI measures as biomarkers or predictors of AD.
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影响因子：
3.3
作者：
H. Yao;Yong Liu;Bo Zhou;Zengqiang Zhang;Ningyu An;Pan Wang;Luning Wang;Xi Zhang;T. Jiang-T.-Ji
通讯作者：
H. Yao;Yong Liu;Bo Zhou;Zengqiang Zhang;Ningyu An;Pan Wang;Luning Wang;Xi Zhang;T. Jiang-T.-Ji
DOI：
10.1016/j.jalz.2014.04.139
发表时间：
2014-07
期刊：
Alzheimer's & Dementia
影响因子：
--
作者：
Nicholas Myers;L. Pasquini;J. Göttler;T. Grimmer;K. Koch;M. Ortner;J. Neitzel;M. Mühlau;S. Förster;A. Kurz;Hans Förstl;C. Zimmer;A. Wohlschläger;V. Riedl;A. Drzezga;C. Sorg
通讯作者：
Nicholas Myers;L. Pasquini;J. Göttler;T. Grimmer;K. Koch;M. Ortner;J. Neitzel;M. Mühlau;S. Förster;A. Kurz;Hans Förstl;C. Zimmer;A. Wohlschläger;V. Riedl;A. Drzezga;C. Sorg
阿尔茨海默病中的长距离功能连接和加权网络架构受损。
影响因子：
3.7
作者：
Liu, Yong;Yu, Chunshui;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
4
作者：
Bajo, Ricardo;Maestu, Fernando;del-Pozo, Francisco
通讯作者：
del-Pozo, Francisco
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V