The SARS-CoV-2 mutation landscape is shaped before replication starts.
The SARS-CoV-2 mutation landscape is shaped before replication starts.
复制标题
DOI：
10.1590/1678-4685-gmb-2023-0005
复制
发表时间：
2023
影响因子：
2.1
通讯作者：
Polo, Luis Mariano
中科院分区：
文献类型：
--
作者：
Masone, Diego;Alvarez, Maria Soledad;Polo, Luis Mariano
SARS-CoV-2中的突变景观和签名已被彻底研究。在这里，我们分析了这些模式，并将它们的变化与呼吸道中的病毒复制组织联系起来。令人惊讶的是，在来自接种疫苗的患者的样品中观察到这些模式的实质性差异。因此，我们提出了一个模型来解释在复制周期中这些突变可能起源于何处。
Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.