Extremely discordant sib-pair study design to determine risk factors for neovascular age-related macular degeneration
Extremely discordant sib-pair study design to determine risk factors for neovascular age-related macular degeneration
复制标题
DOI：
10.1001/archopht.122.4.575
复制
发表时间：
2004-04-01
影响因子：
--
通讯作者：
Miller, JW
中科院分区：
文献类型：
--
作者：
DeAngelis, MM;Lane, AM;Miller, JW
目的：寻找因素，有助于发展的新生血管性年龄相关性黄斑变性（AMD）hash.Methods：在配对病例对照研究中，我们研究了同胞对，其中指数同胞至少有1只眼睛有新生血管性AMD和未受影响的同胞有正常的黄斑（或最多只有几个小玻璃疣），并过去的指数情况下被诊断的年龄。研究的因素包括性别、虹膜颜色、教育、饮酒、体重指数、维生素使用、吸烟史、高胆固醇血症、阿司匹林使用、高血压、其他心血管疾病、任何自身免疫性疾病和非胰岛素依赖型糖尿病。进行条件Logistic回归以确定新生血管性AMD的预测因子。结果：在73个同胞对的基础上，多变量回归分析显示，吸烟每包年新生血管性AMD的风险增加2%，具有统计学意义（比值比，1.02; 95%置信区间，1.01-1.04; P= 0.007）。提示，但不显着的协会也观察到平均终生饮酒量，成人一生的体重指数，高血压在多变量回归analysis.Conclusion：使用极不一致的同胞对AMD的危险因素研究，流行病学设计的一种新方法，我们发现的证据表明，吸烟是一个危险因素，新生血管性AMD。
Objective: To search for factors that contribute to the development of neovascular age-related macular degeneration (AMD).Methods: In a matched-pair case-control study, we studied sib pairs in which the index sibling had neovascular AMD in at least 1 eye and the unaffected sibling had normal maculae (or at most only a few small drusen) and was past the age at which the index case was diagnosed. Factors studied included sex, iris color, education, alcohol consumption, body mass index, vitamin use, smoking history, hypercholesterolemia, aspirin use, hypertension, other cardiovascular disease, any autoimmune disease, and non-insulin-dependent diabetes mellitus. Conditional logistic regression was performed to identify predictors of neovascular AMD.Results: On the basis of 73 sib pairs, multivariate regression analysis revealed statistically significant 2% increase in risk of neovascular AMD with each pack-year of smoking (odds ratio, 1.02; 95% confidence interval, 1.01-1.04; P=.007). Suggestive but nonsignificant associations were also observed for mean lifetime alcohol consumption, adult lifetime body mass index, and hypertension in multivariate regression analyses.Conclusion: Using extremely discordant sib pairs to study risk factors for AMD, a novel approach in epidemiological design, we found evidence that smoking is a risk factor for neovascular AMD.