Association Between Retinol-Binding Protein 4 Concentrations and Gestational Diabetes Mellitus and Risk of Developing Metabolic Syndrome After Pregnancy
Association Between Retinol-Binding Protein 4 Concentrations and Gestational Diabetes Mellitus and Risk of Developing Metabolic Syndrome After Pregnancy
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DOI：
10.1177/1933719109351097
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发表时间：
2010-02-01
影响因子：
2.9
通讯作者：
Larijani, Bagher
中科院分区：
文献类型：
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作者：
Maghbooli, Zhila;Hossein-nezhad, Arash;Larijani, Bagher
本研究的目的是研究血浆视黄醇结合蛋白4(RBP4)与妊娠期糖尿病(GDM)和孕后发生代谢综合征的风险之间的关系。在一项病例对照研究中，招募了192名孕妇(92名妊娠期糖尿病患者)。妊娠期糖尿病的诊断依据O‘Sullivan和Mahan标准。所有孕妇均测定血浆RBP4浓度。妊娠期糖尿病患者的视黄醇结合蛋白4浓度明显高于正常女性。视黄醇结合蛋白4水平大于或等于42mU g/m L有助于预测妊娠期糖尿病的发生(敏感性=75.8%，特异性=65.3%，P=0.05)。001)。关于孕后代谢综合征，根据世界卫生组织(WHO)的标准，在所有参与者中，代谢综合征的患病率为24%。妊娠后，32.6%的妊娠期糖尿病妇女有代谢综合征，而健康妊娠妇女的这一比例为10.5%(P=.001)。年龄>25岁、体重指数(BMI)>27 kg/cm(2)、RBP4浓度是GDM的独立危险因素。对RBP4的测量以及对其他风险因素的评估可以帮助确定有患妊娠期糖尿病风险的妇女。
The aim of this study was to examine the association between plasma retinol-binding protein 4 (RBP4) and gestational diabetes mellitus (GDM) and the risk of developing metabolic syndrome after pregnancy. In a case-control study, 192 pregnant women (92 with GDM) were recruited. Gestational diabetes mellitus was diagnosed based on O'Sullivan and Mahan criteria. In all pregnancies, plasma RBP4 concentrations were measured. Retinol-binding protein 4 concentrations in GDM patients were significantly higher than the normal women. Retinol-binding protein 4 level equal to or more than 42 mu g/mL could help predict the risk of developing GDM (sensitivity = 75.8%, specificity = 65.3%, P =. 001). Concerning metabolic syndrome after pregnancy, in all participants, the prevalence of metabolic syndrome base on World Health Organization (WHO) criteria was 24%. After pregnancy, 32.6% of women with GDM had metabolic syndrome compared with 10.5% of those with healthy pregnancy (P = .001). Age more than 25 years, body mass index (BMI) more than 27 kg/cm(2), and RBP4 concentrations were independent risk factors for GDM. Measurement of RBP4 together with the assessment of other risk factors could help identify women at risk of developing GDM.