Bicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa.
Bicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa.
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DOI：
10.1111/j.1574-6968.2010.01897.x
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发表时间：
2010-03
影响因子：
2.1
通讯作者：
Y. Tashiro;M. Toyofuku;T. Nakajima-Kambe;H. Uchiyama;N. Nomura
中科院分区：
文献类型：
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作者：
Y. Tashiro;M. Toyofuku;T. Nakajima-Kambe;H. Uchiyama;N. Nomura
铜绿假单胞菌分泌膜囊泡（MV），提供几个毒力因子作为货物。我们发现吲哚及其衍生物，包括4-羟基吲哚，5-羟基吲哚，6-羟基吲哚和靛红，抑制MV的产生显着。这些化合物还抑制了假单胞菌喹诺酮信号（PQS）的合成，该信号是上调毒力基因表达并积极控制MV生产的群体感应信号之一。此外，我们发现其他双环化合物，包括1-萘酚，2-萘酚，2，3-二羟基萘，1-氨基萘和8-羟基喹啉，显着抑制MV的生产和PQS的合成。总之，我们提供了新的信息的化学结构，抑制铜绿假单胞菌的毒力。
Pseudomonas aeruginosa secretes membrane vesicles (MVs) that deliver several virulence factors as a cargo. We found that indole and its derivative compounds, including 4-hydroxyindole, 5-hydroxyindole, 6-hydroxyindole and isatin, repress MV production significantly. These compounds also repressed the synthesis of Pseudomonas quinolone signal (PQS), which is one of the quorum-sensing signals that upregulate virulence gene expression and positively control MV production. Moreover, we showed that other bicyclic compounds, including 1-naphthol, 2-naphthol, 2,3-dihydroxynaphthalene, 1-aminonaphthalene and 8-quinolinol, significantly repress MV production and PQS synthesis. In conclusion, we provide new information about the chemical structures that inhibit P. aeruginosa virulence.