Is Sleep Apnea a Winter Disease? Meteorologic and Sleep Laboratory Evidence Collected Over 1 Decade
Is Sleep Apnea a Winter Disease? Meteorologic and Sleep Laboratory Evidence Collected Over 1 Decade
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DOI：
10.1378/chest.11-0493
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发表时间：
2012-12-01
期刊：
影响因子：
9.6
通讯作者：
Goncalves Bos, Angelo Jose
中科院分区：
文献类型：
--
作者：
Cassol, Cristiane Maria;Martinez, Denis;Goncalves Bos, Angelo Jose
背景：阻塞性睡眠呼吸暂停的严重程度在冬季更为常见。检验了不同多导睡眠图患者的呼吸暂停低通气指数（AHI）可能受季节影响的假设。方法：在2000年1月至2009年12月的10年间，回顾性分析了7,523名男女患者的数据库，这些患者接受了实验室基线多导睡眠图检查，以调查任何睡眠障碍的投诉。有关气候和空气污染的数据是从官方机构获得的。AHI是主要的结局变量。余弦分析是一种用于时间序列调查的统计方法，用于检测季节性。结果：余弦分析证实AHI存在年际循环，冬季为高峰，夏季为最低点。即使在调整了性别、年龄、BMI、颈围和相对空气湿度后，季节性也是显著的。天气较冷的6个月AHI中位数（25-75四分位数范围）为17.8 (6.5-40.6/h)，天气较暖的6个月AHI中位数为15.0 （5.7-33.2/h）。AHI与环境温度呈负相关，与大气压力、相对空气湿度和一氧化碳水平直接相关。与降水、空气微粒物质的相关性
Background: The severity of obstructive sleep apnea increases by influence of conditions that are more frequent in winter. The hypothesis that the apnea-hypopnea index (AHI) of different patients undergoing polysomnography may be seasonally affected was tested.Methods: The retrospectively analyzed database included 7,523 patients of both sexes who underwent in-laboratory baseline polysomnography to investigate any complaint of disordered sleep, during 1 decade, between January 2000 and December 2009. Data on climate and air pollution were obtained from official organizations. AHI was the main outcome variable. Cosinor analysis, a statistical method for the investigation of time series, was used to detect seasonality.Results: The cosinor analysis confirmed the existence of a circannual pattern of AHI, with acro-phase in winter and nadir during the summer. The seasonality is significant even after adjusting for sex, age, BMI, neck circumference, and relative air humidity. Median (25-75 interquartile range) AHI in the 6 months with colder weather was 17.8 (6.5-40.6/h), and in the warmer weather was 15.0 (5.7-33.2/h). The AHI correlated inversely with ambient temperature and directly with atmospheric pressure, relative air humidity, and carbon monoxide levels. Correlations with precipitation, particulate air matter