Telomere Length in the Newborn
Telomere Length in the Newborn
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DOI：
10.1203/00006450-200209000-00012
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发表时间：
2002-09
影响因子：
3.6
通讯作者：
K. Okuda;A. Bardeguez;J. Gardner;Paulette Rodriguez;V. Ganesh;M. Kimura;J. Skurnick;G. Awad
中科院分区：
文献类型：
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作者：
K. Okuda;A. Bardeguez;J. Gardner;Paulette Rodriguez;V. Ganesh;M. Kimura;J. Skurnick;G. Awad
端粒长度在人类胎儿的不同器官中是相似的，但在胎儿之间是不同的。在子宫外的生活中，端粒长度在个体之间变化很大，女性比男性长。在目前的工作中，我们解决了以下问题：1)出生时端粒长度是否存在性别差异？2)新生儿体内组织端粒是否存在同步性（即长度相关）？3)新生儿端粒长度的变异是否与成人一样大？我们研究了正常的男性和女性新生儿，他们捐献了三种来源的DNA样本：白细胞、脐带动脉和包皮。端粒长度由末端限制性片段（TRF）的平均长度测定。雄性和雌性新生儿的后翼架长度没有差异。来自白细胞、脐带动脉和皮肤的DNA样本在个体供者中高度同步，但在供者中表现出高度变异性。我们得出的结论是，没有证据表明性别对出生时端粒长度的影响，这表明女性端粒比男性端粒长是因为女性端粒磨损速度较慢。新生儿端粒长度的可变性和新生儿器官端粒长度的同同性与成人端粒长度的变化在很大程度上归因于决定因素（遗传和环境）的概念是一致的，这些决定因素在子宫内开始发挥作用。
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions:1) Are there sex-related differences in telomere length at birth? 2) Is there synchrony (i.e. correlation in length) of telomeres in tissues within the newborn? 3) Is the variability in telomere length among newborns as large as that in adults? We studied normal male and female newborns who donated DNA samples from three sources: white blood cells, umbilical artery, and foreskin. Telomere length was measured by the mean length of the terminal restriction fragments (TRF). TRF length was not different between male and female newborns. It was highly synchronized among the DNA samples from white blood cells, umbilical artery and skin within individual donors but exhibited a high variability among donors. We conclude that there is no evidence for the effect of sex on telomere length at birth, suggesting that longer telomeres in women than men arise from a slower rate of telomeric attrition in women. The variability in telomere length among newborns and synchrony in telomere length within organs of the newborn are consistent with the concept that variations in telomere length among adults are in large part attributed to determinants (genetic and environmental) that start exerting their effect in utero.