Hypoxia-induced autophagy: cell death or cell survival?
Hypoxia-induced autophagy: cell death or cell survival?
复制标题
DOI：
10.1016/j.ceb.2009.11.015
复制
发表时间：
2010-04-01
影响因子：
7.5
通讯作者：
Pouyssegur, Jacques
中科院分区：
文献类型：
--
作者：
Mazure, Nathalie M.;Pouyssegur, Jacques
缺氧（类似于3-0.1%的氧气）能够通过缺氧诱导因子（HIF-1）快速诱导参与自噬的细胞存活反应。这一过程是由非典型的BH 3-only蛋白介导的，Bcl-2/E1 B 19 kDa相互作用蛋白3（BNIP 3/BNIP 3L（NIX））由HIF-1诱导。这些线粒体！相关的BNIP蛋白还介导线粒体自噬，这是一种能够控制活性氧（ROS）产生和DNA损伤的生存代谢适应。相反，严重缺氧或缺氧条件（
Hypoxia (similar to 3-0.1% oxygen) is capable of rapidly inducing, via the hypoxia-inducible factor (HIF-1), a cell survival response engaging autophagy. This process is mediated by the atypical BH3-only proteins the Bcl-2/E1B 19 kDa-interacting protein 3 (BNIP3/BNIP3L (NIX)) that are induced by HIF-1. These mitochondria! associated BNIP proteins also mediate mitophagy, a metabolic adaptation for survival that is able to control reactive oxygen species (ROS) production and DNA damage. In contrast, severe hypoxic conditions or anoxia (