CASE-REPORTS AND HYPOTHESIS - A NEGLECT-LIKE SYNDROME MAY BE RESPONSIBLE FOR THE MOTOR DISTURBANCE IN REFLEX SYMPATHETIC DYSTROPHY (COMPLEX-REGIONAL-PAIN-SYNDROME-1)
CASE-REPORTS AND HYPOTHESIS - A NEGLECT-LIKE SYNDROME MAY BE RESPONSIBLE FOR THE MOTOR DISTURBANCE IN REFLEX SYMPATHETIC DYSTROPHY (COMPLEX-REGIONAL-PAIN-SYNDROME-1)
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DOI：
10.1016/0885-3924(95)00061-3
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发表时间：
1995-07-01
影响因子：
4.7
通讯作者：
JENSEN, MP
中科院分区：
文献类型：
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作者：
GALER, BS;BUTLER, S;JENSEN, MP
反射性交感神经营养不良（RSD，复杂区域疼痛综合征-1，CRPS-1）是一种与自主神经失调相关的慢性疼痛疾病，最常见的是累及肢体。除疼痛外，受累肢体的运动功能障碍可能是残疾的重要原因。为了刺激重新评估潜在的机制和开发新的康复方法RSD，我们提出了一个新的假设：神经忽视样综合征可能解释运动功能障碍，发生在一个亚组的RSD患者。这一假设是基于一个选定的系列的11例患者谁经历了特定的忽视测试。忽视RSD的病因尚不清楚，但我们假设，中枢神经系统（CNS）结构的变化可能会发生持续异常激活的外周和自主神经系统，然后可能会导致忽视样综合征。需要进一步的研究来验证我们的临床观察和测试这一假设。
Reflex sympathetic dystrophy (RSD, Complex Regional Pain Syndrome-1, CRPS-1) is a chronic pain disorder associated with autonomic dysregulation that most commonly involves a limb. In addition to pain, motor dysfunction in the involved extremity may be a significant cause of disability. To spur reassessment of underlying mechanisms and development of novel rehabilitative approaches for RSD, we propose a new hypothesis: a neurologic neglect-like syndrome may explain the motor dysfunction that occurs in a subgroup of RSD patients. This hypothesis is based on a selected series of 11 patients who underwent specific neglect testing. The etiology of neglect in RSD is not clear, but we hypothesize that changes within central nervous system (CNS) structures may occur following persistent abnormal activation of the peripheral and autonomic nervous systems, which then may result in a neglect-like syndrome. Further study is needed to verify our clinical observations and test this hypothesis.