Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity.
Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity.
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DOI：
10.3389/fimmu.2021.661241
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发表时间：
2021
影响因子：
7.3
通讯作者：
Pan W
中科院分区：
文献类型：
--
作者：
Chen JY;Zhou JK;Pan W
作为一种相对成功的病原体，一些寄生虫可以在宿主中建立长期感染。这种“和谐共生”的状态依赖于对宿主免疫和代谢的“精确”操纵，然而，其潜在机制在很大程度上仍然是难以捉摸的。免疫代谢是近年来新兴的交叉学科。主要探讨了代谢变化对免疫细胞活化和效应相关的关键转录和转录后事件重编程的调控机制，为理解寄生虫如何调节宿主的感染和免疫提供了新的视角。本文综述了寄生虫代谢重编程调控免疫细胞功能的研究进展，并展望了寄生虫代谢重编程调控免疫细胞功能的研究前景。
As a relatively successful pathogen, several parasites can establish long-term infection in host. This “harmonious symbiosis” status relies on the “precise” manipulation of host immunity and metabolism, however, the underlying mechanism is still largely elusive. Immunometabolism is an emerging crossed subject in recent years. It mainly discusses the regulatory mechanism of metabolic changes on reprogramming the key transcriptional and post-transcriptional events related to immune cell activation and effect, which provides a novel insight for understanding how parasites regulate the infection and immunity in hosts. The present study reviewed the current research progress on metabolic reprogramming mechanism exploited by parasites to modulate the function in various immune cells, highlighting the future exploitation of key metabolites or metabolic events to clarify the underlying mechanism of anti-parasite immunity and design novel intervention strategies against parasitic infection.
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影响因子：
3.8
作者：
Aravindhan V;Mohan V;Surendar J;Muralidhara Rao M;Pavankumar N;Deepa M;Rajagopalan R;Kumaraswami V;Nutman TB;Babu S
通讯作者：
Babu S
影响因子：
7.3
作者：
de Aguiar Peres, Nalu Teixeira;Seraphim Cunha, Luana Celina;de Almeida, Roque Pacheco
通讯作者：
de Almeida, Roque Pacheco
影响因子：
20.3
作者：
Drach, J;Gsur, A;Huber, H
通讯作者：
Huber, H
影响因子：
20.3
作者：
Everts, Bart;Amiel, Eyal;Pearce, Edward J.
通讯作者：
Pearce, Edward J.
影响因子：
6.7
作者：
Cortes-Selva D;Gibbs L;Maschek JA;Nascimento M;Van Ry T;Cox JE;Amiel E;Fairfax KC
通讯作者：
Fairfax KC