Heterogeneous profiles of coupled sleep oscillations in human hippocampus
Heterogeneous profiles of coupled sleep oscillations in human hippocampus
复制标题
DOI：
10.1016/j.neuroimage.2019.116178
复制
发表时间：
2019-11-15
期刊：
影响因子：
5.7
通讯作者：
Fell, Juergen
中科院分区：
文献类型：
--
作者：
Cox, Roy;Rueber, Theodor;Fell, Juergen
睡眠振荡的交叉频率耦合被认为介导记忆巩固。虽然海马体被认为是这一过程的核心，但关于振荡节律在睡眠中的人类海马体中相互作用的详细知识还缺乏。结合12例神经外科患者的颅内海马和无创脑电图，我们对非快速眼动（NREM）和快速眼动（REM）睡眠期间的频谱功率和耦合进行了表征。海马的耦合是广泛的，大多数通道表达谱相互作用。非快速眼动期持续表现出δ -纹波耦合，但纹波也受到慢振荡和睡眠纺锤波的调制。so - δ和so - θ的耦合，以及δ / θ和纺锤波/ β频率之间的相互作用也发生了。在快速眼动期间，δ / θ和β频率之间出现了有限的相互作用。此外，振荡组织在i)海马和头皮、ii)海马前后轴沿线以及iii)个体之间存在显著差异。总的来说，这些结果扩展并完善了我们对海马体睡眠振荡的理解。
Cross-frequency coupling of sleep oscillations is thought to mediate memory consolidation. While the hippocampus is deemed central to this process, detailed knowledge of which oscillatory rhythms interact in the sleeping human hippocampus is lacking. Combining intracranial hippocampal and non-invasive electroencephalography from twelve neurosurgical patients, we characterized spectral power and coupling during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Hippocampal coupling was extensive, with the majority of channels expressing spectral interactions. NREM consistently showed delta-ripple coupling, but ripples were also modulated by slow oscillations (SOs) and sleep spindles. SO-delta and SO-theta coupling, as well as interactions between delta/theta and spindle/beta frequencies also occurred. During REM, limited interactions between delta/theta and beta frequencies emerged. Moreover, oscillatory organization differed substantially between i) hippocampus and scalp, ii) sites along the anterior-posterior hippocampal axis, and iii) individuals. Overall, these results extend and refine our understanding of hippocampal sleep oscillations.