Patterns of conservation and change in honey bee developmental genes
Patterns of conservation and change in honey bee developmental genes
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DOI：
10.1101/gr.5108606
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发表时间：
2006-11-01
期刊：
影响因子：
7
通讯作者：
Beye, Martin
中科院分区：
文献类型：
--
作者：
Dearden, Peter K.;Wilson, Megan J.;Beye, Martin
当前的昆虫基因组测序项目为扩展昆虫发育基因和途径的进化研究提供了机会。在本文中，我们研究了果蝇和蜜蜂之间基因的保守性和差异以及发育过程。通过比较蜜蜂中是否存在 308 个果蝇发育基因，我们发现了两种全变态昆虫，它们的谱系分离时间与 3 亿年前相似。通过检查保守通路（细胞信号传导、轴形成、分割和同源框转录因子）中涉及的基因是否存在，我们发现绝大多数基因是保守的。然而，参与这些过程的一些基因在蜜蜂中缺失。我们还检查了果蝇基因的直系同源性，这些基因涉及蜜蜂和果蝇之间不同的过程。这些基因中的许多都保留在蜜蜂中，尽管它们在果蝇中的作用过程与蜜蜂中不同或不存在。这两种情况下的许多缺失基因似乎都是最近在果蝇谱系中出现的，在果蝇中具有单一的已知功能，并且在发育途径的早期发挥作用，而那些被保留的基因则具有多效性功能。这些数据的进化解释是，要么共同祖先中具有多种功能的基因更有可能保留在两个昆虫谱系中，要么在整个进化过程中保留的基因更有可能选择额外的功能。
The current insect genome sequencing projects provide an opportunity to extend studies of the evolution of developmental genes and pathways in insects. In this paper we examine the conservation and divergence of genes and developmental processes between Drosophila and the honey bee; two holometabolous insects whose lineages separated similar to 300 million years ago, by comparing the presence or absence of 308 Drosophila developmental genes in the honey bee. Through examination of the presence or absence of genes involved in conserved pathways (cell signaling, axis formation, segmentation and homeobox transcription factors), we find that the vast majority of genes are conserved. Some genes involved in these processes are, however, missing in the honey bee. We have also examined the orthology of Drosophila genes involved in processes that differ between the honey bee and Drosophila. Many of these genes are preserved in the honey bee despite the process in which they act in Drosophila being different or absent in the honey bee. Many of the missing genes in both situations appear to have arisen recently in the Drosophila lineage, have single known functions in Drosophila, and act early in developmental pathways, while those that are preserved have pleiotropic functions. An evolutionary interpretation of these data is that either genes with multiple functions in a common ancestor are more likely to be preserved in both insect lineages, or genes that are preserved throughout evolution are more likely to co-opt additional functions.