Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.
Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.
复制标题
人单核细胞白血病细胞系 (THP-1) 合成并分泌载脂蛋白 E 和脂蛋白脂肪酶。
DOI：
10.1016/0006-291x(85)90637-0
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
A. Yamamoto
中科院分区：
文献类型：
--
作者：
S. Tajima;R. Hayashi;S. Tsuchiya;Y. Miyake;A. Yamamoto
A human cell line established from a patient of an acute monocytic leukemia (THP-1) retained an ability to synthesize and secrete plasma apolipoprotein E like protein. The protein was identified with monospecific antibody raised against human plasma apolipoprotein E. The cells also secreted lipoprotein lipase (EC 3.1.1.34). The enzyme was characterized as lipoprotein lipase on the basis of the requirement of apolipoprotein C-II as an activator and the inhibition of its activity by sodium chloride. The secretion of both apolipoprotein E and lipoprotein lipase was markedly enhanced in the process of differentiation into macrophage-like cells by the addition of 4β-phorbol 12β-myristate 13α-acetate.
培养物中巨噬细胞分泌脂蛋白脂肪酶。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Khoo,JC;Mahoney,EM;Witztum,JL
通讯作者：
Witztum,JL