Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs
Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs
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DOI：
10.1152/ajpendo.1997.272.5.e877
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发表时间：
1997-05-01
影响因子：
5.1
通讯作者：
Nguyen, HV
中科院分区：
文献类型：
--
作者：
Davis, TA;Fiorotto, ML;Nguyen, HV
本研究旨在探讨宫内生长限制（IUGR）对新生猪组织蛋白合成对饲粮急性反应的影响。在整个妊娠期间分别饲喂对照饲粮和蛋白质限制饲粮的母猪新生猪被指定为C或IUGR，两组仔猪在出生后禁食9 h，或在禁食6 h后每小时饲喂30 ml初乳/kg体重，持续2.75 h。用L-[4-H-3]苯丙氨酸在体内测量组织蛋白合成的分数率（K-s）。IUGR猪的出生体重降低了33%。IUGR对骨骼肌、心脏、肝脏、空肠和胰腺的K-s没有影响。在C和IUGR猪中，喂养对组织K-s的刺激相似。空腹血浆胰岛素浓度及其随饲喂的升高不受IUGR的影响。IUGR猪的血浆胰岛素样生长因子I（IGF-I）浓度降低了42%，IUGR猪和C猪的饲喂均未改变血浆胰岛素样生长因子I浓度。组织k值与胰岛素循环浓度呈非线性正相关。结果表明，新生猪的组织K-s不受IUGR的影响，尽管血浆IGF-I浓度降低。营养物质刺激组织K-s的效率也不会因IUGR而改变，这可能是因为饲喂时血浆胰岛素浓度的升高不受IUGR的影响。
This study aimed to determine the effect of intrauterine growth restriction (IUGR) on the acute response of tissue protein synthesis to feeding in newborn pigs. Newborn pigs of sows fed either control or protein-restricted diets throughout gestation were designated C or IUGR, respectively Both groups were either fasted for 9 h after birth or fed hourly 30 ml colostrum/kg body wt for 2.75 h after a 6-h fast. Fractional rates of tissue protein synthesis (K-s) were measured in vivo with a flooding dose of L-[4-H-3]phenylalanine. Birth weight was reduced by 33% in IUGR pigs. IUGR had no effect on K-s in skeletal muscles, heart, liver, jejunum, or pancreas. Feeding stimulated tissue K-s similarly in C and IUGR pigs. Fasting plasma insulin concentrations and their rise with feeding were unaffected by IUGR. Plasma insulin-like growth factor I(IGF-I) concentrations were reduced by 42% in IUGR pigs and were not altered by feeding in either IUGR or C pigs. There were positive nonlinear relationships between tissue Ks and circulating concentrations of insulin. The results indicate that, in newborn pigs, tissue K-s are unaffected by IUGR, despite reduced plasma IGF-I concentrations. The efficiency with which nutrients stimulate tissue K-s is also not altered by IUGR, perhaps because the rise in plasma insulin concentrations with feeding is unaffected by IUGR.