Correlation of HER-2/neu overexpression with mammography and age distribution in primary breast carcinomas
Correlation of HER-2/neu overexpression with mammography and age distribution in primary breast carcinomas
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DOI：
10.1016/j.acra.2006.06.015
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发表时间：
2006-10-01
影响因子：
4.8
通讯作者：
Lee, Juneyoung
中科院分区：
文献类型：
--
作者：
Seo, Bo Kyoung;Pisano, Etta D.;Lee, Juneyoung
基本原理和目标。HER-2/neu是原发性乳腺癌有价值的预后和治疗指标。本研究的目的是确定与原发性乳腺癌中HER-2/neu过表达相关的乳房x线摄影和患者特征（年龄）。材料与方法。498例543例原发性乳腺癌（526例浸润性癌和17例导管原位癌）的HER-2/neu特征和术前乳房x线照片均可获得。免疫组织化学和荧光原位杂交检测HER-2/neu状态。为评价患者年龄分布，将患者年龄分为5组。对于乳房x光检查，乳房成分和异常发现被分类。异常表现分为肿块、钙化、结构扭曲、密度不对称或无异常。年龄分布方面，50岁以下女性HER-2/ new过表达频率高于60-69岁女性（P < 0.05）。HER-2/neu过表达的癌患者（56%）比HER-2/neu未过表达的癌患者（40%）钙化更频繁（P = 0.001）。在242例乳房x线检查伴有钙化的癌中，HER-2/neu过表达的癌（20%）比HER-2/neu未过表达的癌（10%）更频繁出现细线形形态（P = 0.023）。HER-2/neu过表达的癌（11%）比HER-2/neu未过表达的癌（5%）弥漫性钙化更常见（P = 0.051）。HER-2/neu在原发性乳腺癌中的过表达与患者年龄（50岁以下）和乳房x光检查中的钙化相关。
Rationale and Objectives. HER-2/neu is a valuable prognostic and therapeutic marker in primary breast carcinoma. The objective of this study was to determine the mammographic and patient characteristics (age) that correlate with HER-2/neu overexpression in primary breast carcinoma.Materials and Methods. HER-2/neu characteristics and preoperative mammograms were available in 498 patients with 543 primary breast carcinomas (526 invasive carcinomas and 17 ductal carcinoma in situ). HER-2/neu status was determined by immunohistochemistry and fluorescence in situ hybridization. For evaluation of patient age distribution, age was divided into 5 groups. For mammography, breast composition and abnormal findings were categorized. Abnormal findings were divided into mass, calcification, architectural distortion, asymmetric density, or none.Results. For age distribution, women under than 50 years had more frequent HER-2/neu overexpression than women aged 60-69 years (P .05). Calcifications were more significantly frequent in carcinomas with HER-2/neu overexpression (56%) than in those without HER-2/neu overexpression (40%) (P =.001). Of the 242 carcinomas with calcifications on mammography, fine linear morphology was more significantly frequent in carcinomas with HER-2/neu overexpression (20%) when compared with those without HER-2/neu overexpression (10%) (P =.023). Diffuse distribution of calcifications was more common in carcinomas with HER-2/neu overexpression (11%) compared with carcinomas without HER-2/neu overexpression (5%) (P =.051).Conclusion. HER-2/neu overexpression in primary breast carcinoma is correlated with patients' age (under age 50) and calcifications at mammography.