Centrally mediated vasopressor effect of angiotensin II in man.
Centrally mediated vasopressor effect of angiotensin II in man.
复制标题
血管紧张素 II 在人体中的中枢介导的血管加压作用。
DOI：
10.1536/ihj.10.243
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
S. Katayama
中科院分区：
文献类型：
--
作者：
H. Ueda;Y. Uchida;K. Ueda;T. Gondaira;S. Katayama
在人体脊椎和主动脉注射合成的血管紧张素Ⅱ（AngiotensinII，Ang Ⅱ），观察其对体循环动脉压和心率的影响，结果表明：注射剂量为0.016 ~ 0.06μg/ml的Ang Ⅱ，对体循环动脉压和心率的影响不明显。Kg.结果显示：1）脊椎注射血管紧张素II引起的体循环动脉压升高高于相同剂量的主动脉注射; 2）脊椎注射小剂量时心率增加，而主动脉注射时心率降低。从这些数据可以认为，脊椎注射血管紧张素II引起血压升高的部分原因是交感神经活动增加。
Responses to vertebral and aortic injection of synthetized angiotensin II of the systemic arterial pressure and heart rate were examined in humans and the following results were obtained:Angiotensin II injections in the dosages from 0.016 to 0.06μg./Kg. caused the following effects.1) Vertebral injection produced a higher rise in the systemic arterial pressure than that produced by aortic injection of the same dose.2) Heart rate was increased by vertebral injection of a small dose, but was decreased by aortic injection.From these data, it was considered that vertebral injection of angiotensin II in humans caused a rise in blood pressure partly by increasing the sympathetic nerve activity.