Membrane Exporters of Fluoride Ion.
Membrane Exporters of Fluoride Ion.
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DOI:
10.1146/annurev-biochem-071520-112507
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发表时间:
2021-06-20
影响因子:
16.6
通讯作者:
Stockbridge RB
中科院分区:
文献类型:
--
作者:
McIlwain BC;Ruprecht MT;Stockbridge RB
Microorganisms contend with numerous and unusual chemical threats, and have evolved a catalogue of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F−), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years in understanding the microbial response to cytoplasmic accumulation of F−, with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride, the CLCF family of F−/H+ antiporters, and the Fluc/FEX family of F− channels.
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Doyle, DA;Cabral, JM;MacKinnon, R
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10.1085/jgp.201411225
发表时间:
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期刊:
The Journal of general physiology
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10.1016/j.ijantimicag.2019.02.003
发表时间:
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Krappmann, Sven