Membrane Exporters of Fluoride Ion.

Membrane Exporters of Fluoride Ion.
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DOI:
10.1146/annurev-biochem-071520-112507
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发表时间:
2021-06-20
影响因子:
16.6
通讯作者:
Stockbridge RB
Stockbridge RB
中科院分区:
生物学1区
文献类型:
--
作者:
McIlwain BC;Ruprecht MT;Stockbridge RB

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微生物与众多和不寻常的化学威胁作斗争,并进化出一系列抗性机制作为回应。一个特别古老的有害威胁是氟离子(F−),这是自然环境中常见的异生物质,对代谢途径造成广谱危害。本文综述了过去十年来在理解微生物对F-胞质积累的反应方面的进展,特别强调了微生物用于输出氟化物的蛋白质的结构和机制,CLCF家族的F-/H+反向转运蛋白,以及Fluc/FEX家族的F-通道。
Microorganisms contend with numerous and unusual chemical threats, and have evolved a catalogue of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F−), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years in understanding the microbial response to cytoplasmic accumulation of F−, with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride, the CLCF family of F−/H+ antiporters, and the Fluc/FEX family of F− channels.
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