Arousal-mediated memory consolidation: Role of the medial temporal lobe in humans
Arousal-mediated memory consolidation: Role of the medial temporal lobe in humans
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DOI：
10.1111/1467-9280.00090
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发表时间：
1998-11-01
影响因子：
8.2
通讯作者：
Phelps, EA
中科院分区：
文献类型：
--
作者：
LaBar, KS;Phelps, EA
尽管情绪唤起对陈述性记忆的影响已在行为上得到记录，但唤起-记忆相互作用的机制及其在人脑中的表现仍然不确定。唤醒对记忆性能产生影响的一种途径是调节巩固过程。动物研究表明，杏仁核在参与唤醒任务后的有限时间窗口内加强了海马依赖性记忆巩固。为了检查杏仁核-海马结构的这种整合功能是否延伸到人脑，我们测试了单侧颞叶切除术患者对经典范例的适应，其中编码时的生理唤醒水平随着时间的推移调节保留。受试者在唤醒量表上对情绪唤醒（禁忌）和中性词语进行评分，同时监测他们的皮肤电导反应（SCR），立即并在延迟一小时后评估对词语的回忆。颞叶切除术患者和对照受试者在编码时对唤醒词产生了增强的 SCR 和唤醒评级。然而;随着时间的推移，只有对照组受试者对激发性词语的记忆力有所增强。唤醒对遗忘率影响的群体差异表明，内侧颞叶结构在唤醒事件的记忆巩固中的作用在不同物种中是保守的。
Although the influence of emotional arousal on declarative memory has been documented behaviorally the mechanisms underlying arousal-memory interactions and their representation in the human brain remain uncertain. One route through which arousal achieves its effects on memory performance is by regulating consolidation processes. Animal research has revealed that the amygdala strengthens hippocampal-dependent memory consolidation in a limited time window following participation in an arousing task. To examine whether this integrative function of amygdalo-hippocampal structures extends to the human brain, we tested unilateral-temporal-lobectomy patients on an adaptation of a classic paradigm in which levels of physiological arousal at encoding modulate retention over time. Subjects rated emotionally arousing (taboo) and neutral words on an arousal scale while their skin conductance responses (SCRs) were monitored Recall for the words was assessed immediately and after a I-hr delay. Both temporal-lobectomy patients and control subjects generated enhanced SCRs and arousal ratings for the arousing words at the time of encoding. However; only control subjects exhibited an increase in memory for the arousing words over time. This group difference in the effect of arousal on the rate of forgetting suggests that the role of medial temporal lobe structures in memory consolidation for arousing events is conserved across species.