Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery
Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery
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介孔硅酸盐不同结构通道对布洛芬控制释放的影响
DOI：
10.1016/j.matchemphys.2012.05.059
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发表时间：
2012-08-15
影响因子：
4.6
通讯作者：
Ren, Bo
中科院分区：
文献类型：
--
作者：
Gao, Lin;Sun, Jihong;Ren, Bo
以3-(2-氨基乙氨基)丙基三甲氧基硅烷为布洛芬载体，合成了具有短无规介孔孔道的双峰介孔二氧化硅和具有长有序介孔的MCM-41，研究了介孔结构对药物释放性能的影响。为了进一步比较不同的介孔通道，还合成了具有较大和较长有序介孔的改性SBA-15作为药物载体。用X射线衍射仪、扫描电子显微镜、透射电子显微镜、傅立叶变换红外光谱、N-2吸附-脱附等温线、热重分析、固体Si-29核磁共振谱、元素分析和UV-Vis谱对样品进行了表征。同时，采用Korsmeyer-Peppas方程f(T)=kt(N)分析药物释放曲线，并以模拟液体溶液、蒸馏水和模拟胃液为释放介质。结果表明，具有双峰介孔的改性BMMS的载药量最大，为25.0 mg/0.1g，而具有长一维介孔的MCM-41的载药量最小，为20.3 mg/0.1g。同时，药物分子在BMMS的双峰中孔孔道中较易扩散，与MCM-41相比具有较快的释药性能，而在SBF中的释药时间约为12h(释放百分率约为90wt%)，由Korsmeyer-Peppas方程得到的释放常数k约为4.10。(C)2012爱思唯尔B.V.保留所有权利。
The bimodal mesoporous silicas with short random mesoporous channels and MCM-41 with long ordered mesopores were synthesised and modified with 3-(2-aminoethylamino) propyltrimethoxysilane as ibuprofen carriers to study the influence of mesoporous structure on drug delivery property. For further comparing the different mesoporous channels, modified SBA-15 with relative large and long ordered mesopores was also synthesized as drug carriers. The resultant samples were characterized with X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectra, N-2 adsorption-desorption isotherms, thermogravimetric analyses, solid-state Si-29 NMR spectra, elemental analysis, and UV-vis spectra. Meanwhile, the Korsmeyer-Peppas equation f(t) = kt(n) was employed to analyze the drug release profile and three release mediums including simulated fluid solution, distilled water and simulated gastric fluid were used. The results indicated that the modified BMMs with the bimodal mesopores leaded to the most drug loading amount of 25.0 mg/0.1 g, while the MCM-41 with the long and one-dimensional mesopores had the least loading amount around 20.3 mg/0.1 g. Meanwhile, the easier diffusion behavior of drug molecules in the bimodal mesopore channels of BMMs resulted in relatively faster drug release properties in comparison with MCM-41, while the release time maintained in SBF for about 12 h (release percent was about 90 wt%) and corresponding release constant k obtained from Korsmeyer-Peppas equation was around 4.10. (C) 2012 Elsevier B.V. All rights reserved.