A role for oxygen radicals as second messengers.
A role for oxygen radicals as second messengers.
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DOI：
10.1016/0962-8924(91)90072-h
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发表时间：
1991-08-01
影响因子：
19
通讯作者：
Baeuerle, P A
中科院分区：
文献类型：
--
作者：
Schreck, R;Baeuerle, P A
所有细胞似乎都产生氧自由基。最近的研究结果表明，在肿瘤坏死因子（TNF）、白细胞介素1 （IL-1）和佛波酯的刺激下，各种细胞类型释放少量无毒的这些自由基，所有这些自由基都通过释放抑制蛋白亚基激活细胞质形式的转录因子nf - κ B。激活被去除氧自由基的药剂所抑制，并被暴露于温和的氧化应激所模拟。本文提出，在至少一种激活NF-kappa B的调节途径中，氧自由基作为多种药物的第二信使，包括免疫调节细胞因子TNF和IL-1。
All cells seem to produce oxygen radicals. Recent results suggest that small nontoxic amounts of these radicals are released by various cell types in response to stimulation with tumour necrosis factor (TNF), interleukin 1 (IL-1) and phorbol esters, all of which activate a cytoplasmic form of the transcription factor NF-kappa B by releasing an inhibitory protein subunit. Activation is inhibited by agents that remove oxygen radicals, and mimicked by exposure to mild oxidant stress. This article proposes that oxygen radicals act as second messengers for a variety of agents, including the immunomodulatory cytokines TNF and IL-1, in at least one type of regulatory pathway activating NF-kappa B.