The bactericidal/permeability-increasing protein (BPI) in the innate defence of the lower airways
The bactericidal/permeability-increasing protein (BPI) in the innate defence of the lower airways
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DOI：
10.1042/bst0391045
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发表时间：
2011-08-01
影响因子：
3.9
通讯作者：
Gessner, Andre
中科院分区：
文献类型：
--
作者：
Holweg, Alexander;Schnare, Markus;Gessner, Andre
人的BPI(杀菌/通透性增加蛋白)储存在中性粒细胞的初级天青颗粒中，由粘膜上皮细胞产生，几十年来一直被认为能以非常高的亲和力结合脂多糖(LPS)，并有效地杀灭革兰氏阴性细菌。因此，BPI潜在地代表了先天免疫系统的中心组成部分，直接对抗微生物并调节随后的获得性免疫反应。特别是在经常接触各种吸入性病原体的肺部，BPI等抗菌天然防御分子具有特殊的相关性。在这篇综述中，我们强调了BPI在急性肺炎和肺囊性纤维化相关的慢性感染中的可能作用。
The human BPI (bactericidal/permeability-increasing protein), stored in primary azurophilic granula of neutrophil granulocytes and produced by mucosal epithelia, has been known for decades to bind LPS (lipopolysaccharide) with very high affinity and to efficiently kill Gram-negative bacteria. Thus BPI potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses. Especially in the lungs, which are frequently exposed to a variety of inhaled pathogens, antimicrobial innate defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung.