Rapid prototyping for neuroscience and neural engineering.
Rapid prototyping for neuroscience and neural engineering.
复制标题
神经科学和神经工程的快速原型设计。
DOI：
10.1016/j.jneumeth.2008.03.011
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发表时间：
2008
影响因子：
3
通讯作者：
Rousche,PatrickJ
中科院分区：
文献类型：
--
作者：
Tek,Peter;Chiganos,TerryC;Mohammed,JaveedShaikh;Eddington,DavidT;Fall,ChristopherP;Ifft,Peter;Rousche,PatrickJ
快速成型（RP）是设计和制造用于神经科学研究的各种设备的有用方法。本研究证实了使用熔融沉积成型，RP的一种特定形式，生产三种常用的基础科学实验设备的实用性。RP方法的准确度和精度根据打印机的类型和质量以及热塑性基板而变化。打印机能够根据制造方向创建最小直径为0.4或0.6 mm的器械通道。RP实现了三种定制设备的计算机辅助设计和制造，包括能够在缺血激发期间监测电生理功能的皮质记录/卒中诱导平台。除了记录平台外，还以亚毫米精度复制了两个灌注室和一个颅窗装置。以最小的努力和较短的周转时间重复修改每个设备的设计的能力有助于经常不可预测的实验条件。从使用皮质记录平台和灌注室的确认研究中获得的结果与使用传统手工制造或市售器械的先前结果没有差异。结合计算机辅助设计，快速成型是开发和制造神经科学研究定制设备的绝佳选择。
Rapid prototyping (RP) is a useful method for designing and fabricating a wide variety of devices used for neuroscience research. The present study confirms the utility of using fused deposition modeling, a specific form of RP, to produce three devices commonly used for basic science experimentation. The accuracy and precision of the RP method varies according to the type and quality of the printer as well as the thermoplastic substrate. The printer was capable of creating device channels with a minimum diameter of 0.4 or 0.6mm depending on the orientation of fabrication. RP enabled the computer-aided design and fabrication of three custom devices including a cortical recording/stroke induction platform capable of monitoring electrophysiological function during ischemic challenge. In addition to the recording platform, two perfusion chambers and a cranial window device were replicated with sub-millimeter precision. The ability to repeatedly modify the design of each device with minimal effort and low turn-around time is helpful for oft-unpredictable experimental conditions. Results obtained from validation studies using both the cortical recording platform and perfusion chamber did not vary from previous results using traditional hand-fabricated or commercially available devices. Combined with computer-aided design, rapid prototyping is an excellent alternative for developing and fabricating custom devices for neuroscience research.