Mechanisms of drug combinations: interaction and network perspectives
Mechanisms of drug combinations: interaction and network perspectives
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DOI：
10.1038/nrd2922-c1
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发表时间：
2009-06
影响因子：
120.1
通讯作者：
J. Jia;F. Zhu;Xiaohua Ma;Zhiwei Cao;Yixue Li;Y. Chen
中科院分区：
文献类型：
--
作者：
J. Jia;F. Zhu;Xiaohua Ma;Zhiwei Cao;Yixue Li;Y. Chen
了解药物组合的协同、增效和拮抗作用的分子机制有助于发现新的有效组合和多靶点药物。在这篇文章中，我们描述了一个广泛的调查，已发表的文献中的药物组合的组合效果进行了评估，通过严格的分析方法和相关的分子相互作用的药物的配置文件。对117种确定的药物组合的分析揭示了一般和特定的作用模式，并突出了分子相互作用谱在发现新型多组分疗法中的潜在价值。
Understanding the molecular mechanisms underlying synergistic, potentiative and antagonistic effects of drug combinations could facilitate the discovery of novel efficacious combinations and multi-targeted agents. In this article, we describe an extensive investigation of the published literature on drug combinations for which the combination effect has been evaluated by rigorous analysis methods and for which relevant molecular interaction profiles of the drugs involved are available. Analysis of the 117 drug combinations identified reveals general and specific modes of action, and highlights the potential value of molecular interaction profiles in the discovery of novel multicomponent therapies.