Hemolymph coagulation and phenoloxidase in Drosophila larvae
Hemolymph coagulation and phenoloxidase in Drosophila larvae
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DOI：
10.1016/j.dci.2004.11.007
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Dushay, MS
中科院分区：
文献类型：
--
作者：
Bidla, G;Lindgren, M;Dushay, MS
血淋巴凝固是昆虫对受伤的第一反应。尽管已经对大蜡螟等大型昆虫进行了研究，但对黑腹果蝇的凝血知之甚少，果蝇是对先天免疫的遗传和分子分析最有用的昆虫。在这里，我们通过光学显微镜和电子显微镜展示了果蝇和圆果蝇凝块之间的相似性。酚氧化酶通过交联和黑化改变果蝇凝块的物理性质，但这对于初步软凝块的形成不是必需的。细菌与凝块结合，但仅凭这一点并不一定会杀死它们。现在我们对昆虫血淋巴凝固、其在免疫防御和伤口愈合中的作用的理解以及对昆虫免疫系统的总体了解的更全面的了解已经准备好。 (c) 2005 Elsevier Ltd. 保留所有权利。
Hemolymph coagulation is a first response to wounding in insects. Although studies have been performed in large-bodied insects such as the moth Galleria mellonella, less is known about clotting in Drosophila melanogaster, the insect most useful for genetic and molecular analyses of innate immunity. Here we show the similarities between clots in Drosophila and Galleria by light- and electron microscopy. Phenoloxidase changes the Drosophila clot's physical properties through cross-linking and melanization, but it is not necessary for preliminary soft clot formation. Bacteria associate with the clot, but this alone does not necessarily kill them. The stage is now set for rapid advances in our understanding of insect hemolymph coagulation, its roles in immune defense and wound healing, and for a more comprehensive grasp of the insect immune system in general. (c) 2005 Elsevier Ltd. All rights reserved.