Cancer associated fibroblasts in cancer pathogenesis.
Cancer associated fibroblasts in cancer pathogenesis.
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DOI：
10.1016/j.semcdb.2009.10.010
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发表时间：
2010-02
影响因子：
7.3
通讯作者：
Hayward SW
中科院分区：
文献类型：
--
作者：
Franco OE;Shaw AK;Strand DW;Hayward SW
在过去的一个世纪里，我们对癌细胞生长和侵袭特性所涉及的分子机制的理解逐渐但持续地取得进展，这使得肿瘤的治疗效果得到了改善。然而，许多肿瘤仍然不受调控，发展为晚期疾病。直到最近，人们才开始对肿瘤附近的“正常”细胞进行有组织且持续的关注。肿瘤与这些宿主细胞之间的相互作用，以及宿主细胞自身的自主特性，或许可以解释为什么组织学上相似的癌症患者的肿瘤在行为和对治疗的反应上常常存在差异。肿瘤微环境中的细胞，有多种称呼，如癌症间质、反应性间质或癌相关成纤维细胞（CAF），它们紧邻癌上皮细胞。在肿瘤发生过程中，间质和上皮表型共同进化，现在越来越清楚的是，这些间质细胞可能并非人们普遍认为的无辜旁观者，而是癌症发生的积极参与者。我们的研究小组和其他一些研究小组已经表明了CAF在癌症进展中所起的重要作用。在本文中，我们将探讨不同器官中癌症间质与肿瘤细胞相互作用研究的当前趋势。我们还将强调已知的知识空白，并提出需要进一步探索的研究领域，以便为抗癌治疗提供新的靶点。
In the past century, gradual but sustained advances in our understanding of the molecular mechanisms involved in the growth and invasive properties of cancer cells have led to better management of tumors. However, many tumors still escape regulation and progress to advanced disease. Until recently, there has not been an organized and sustained focus on the “normal” cells in the vicinity of tumors. Interactions between the tumor and these host cells, as well as autonomous qualities of the host cells themselves, might explain why tumors in people with histologically similar cancers often behave and respond differently to treatment. Cells of the tumor microenvironment, variously referred to as cancer stroma, reactive stroma or carcinoma associated fibroblasts (CAF), exist in close proximity to the cancer epithelium. Both stromal and epithelial phenotypes co-evolve during tumorigenesis and it is now becoming clear that these stromal cells may not be the innocent bystanders they had been widely thought to be, but rather may be active contributors to carcinogenesis. Our group and others have shown the important role that CAF play in the progression of cancer. In this article we will address current trends in the study of the interactions between cancer stroma and tumor cells in different organs. We will also highlight perceived knowledge gaps and suggest research areas that need to be further explored to provide new targets for anti-cancer therapies.
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影响因子：
7.4
作者：
Grover, AC;Tangrea, MA;Libutti, SK
通讯作者：
Libutti, SK
影响因子：
11.2
作者：
Cheng, Nikki;Chytil, Anna;Mosesi, Harold L.
通讯作者：
Mosesi, Harold L.
影响因子：
11.2
作者：
Grum-Schwensen, B;Klingelhofer, J;Ambartsumian, N
通讯作者：
Ambartsumian, N
影响因子：
11.2
作者：
Ao, Mingfang;Williams, Karin;Hayward, Simon W.
通讯作者：
Hayward, Simon W.
影响因子：
64.8
作者：
Karnoub, Antoine E.;Dash, Ajeeta B.;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.