The nucleolus and herpesviral usurpation
The nucleolus and herpesviral usurpation
复制标题
核仁和疱疹病毒侵占
DOI：
10.1099/jmm.0.045963-0
复制
发表时间：
2012
影响因子：
3
通讯作者：
Zheng Chunfu
中科院分区：
文献类型：
--
作者：
Ni Liwen;Wang Shuai;Zheng Chunfu
在真核生物中，核仁是一个独特的亚核区室，是核糖体生物发生的场所。因此，核仁也被认为在细胞周期控制、应激感应和衰老以及病毒感染中起作用。越来越多的病毒蛋白被发现定位于核仁。在这篇文章中，我们回顾了目前对核仁功能的认识，细胞和病毒蛋白靶向核仁的分子机制以及核仁在病毒感染过程中的功能作用，并特别关注疱疹病毒家族。
The nucleolus is a distinct subnuclear compartment known as the site for ribosome biogenesis in eukaryotes. Consequently, the nucleolus is also proposed to function in cell-cycle control, stress sensing and senescence, as well as in viral infection. An increasing number of viral proteins have been found to localize to the nucleolus. In this article, we review the current understanding of the functions of the nucleolus, the molecular mechanism of cellular and viral protein targeting to the nucleolus and the functional roles of the nucleolus during viral infection with a specific focus on the herpesvirus family.