Somatosensory pleasure circuit: from skin to brain and back
Somatosensory pleasure circuit: from skin to brain and back
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DOI：
10.1111/exd.12639
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发表时间：
2015-05-01
影响因子：
3.6
通讯作者：
Yosipovitch, Gil
中科院分区：
文献类型：
--
作者：
Lloyd, Donna M.;McGlone, Francis P.;Yosipovitch, Gil
皮肤感觉具有辨别功能，允许我们操纵物体并检测触摸和温度，以及情感/情绪功能，当皮肤受损时表现为瘙痒或疼痛。两种不同类型的神经纤维介导皮肤躯体感觉的这些可分离方面：（i）有髓鞘的A-β和A-δ传入，其提供关于皮肤接触的位置和物理特征的快速信息;和（ii）无髓鞘的、传导缓慢的C-纤维传入，其通常与编码疼痛和瘙痒的情感特性相关。然而，最近的研究已经确定了第三类C纤维传入，它们编码触摸-触觉传入或CT的愉悦特性。在未来，以舒适的CT介导的触摸（如按摩疗法）为目标的治疗的临床应用可以提供一种补充的非药物手段，用于治疗慢性皮肤病（如瘙痒和湿疹）的生理和心理方面。
The skin senses serve a discriminative function, allowing us to manipulate objects and detect touch and temperature, and an affective/emotional function, manifested as itch or pain when the skin is damaged. Two different classes of nerve fibre mediate these dissociable aspects of cutaneous somatosensation: (i) myelinated A-beta and A-delta afferents that provide rapid information about the location and physical characteristics of skin contact; and (ii) unmyelinated, slow-conducting C-fibre afferents that are typically associated with coding the emotional properties of pain and itch. However, recent research has identified a third class of C-fibre afferents that code for the pleasurable properties of touch - c-tactile afferents or CTs. Clinical application of treatments that target pleasant, CT-mediated touch (such as massage therapy) could, in the future, provide a complementary, non-pharmacological means of treating both the physical and psychological aspects of chronic skin conditions such as itch and eczema.