Fetal Chromosome Analysis After Transcervical Placental Biopsies During Early Pregnancy
Fetal Chromosome Analysis After Transcervical Placental Biopsies During Early Pregnancy
复制标题
妊娠早期经宫颈胎盘活检后的胎儿染色体分析
DOI：
10.3109/00016347309157092
复制
发表时间：
1973
影响因子：
4.3
通讯作者：
B. Sandahl
中科院分区：
文献类型：
--
作者：
S. Kullander;B. Sandahl
抽象的。使用直径 5 毫米的宫颈内镜和光纤系统，可以在人类妊娠早期（8 至 20 周）期间通过宫颈管对绒毛膜进行活检。对39名申请合法堕胎的患者进行了检查。 2-3 周后，41 次测试中有 20 次获得了组织培养生长，并具有足够数量的有丝分裂图用于性别鉴定和染色体分析。活检标本的核型被发现正常，并且与合法流产的胎儿的性别一致。活检后 7 至 43 天观察的 19 例患者在此期间没有出现任何妊娠障碍。讨论了该技术的实际用途，并在两例即将堕胎的案例中进行了尝试。
Abstract. With an endocervicoscope 5 mm in diameter, and a fibre‐optic system, it was possible to biopsy the chorion through the cervical canal, during early human pregnancies from 8 to 20 weeks of duration. 39 patients who applied for legal abortion were examined. Growth in tissue culture, with a sufficient number of mitotic figures for sexing and chromosomal analysis was obtained in 20 out of 41 tests after 2–3 weeks. The karyotypes from the biopsy specimens were found to be normal and agreed with respect to sex with the legally aborted fetuses. 19 cases observed for between 7 and 43 days following the biopsy did not show any disturbance of the pregnancy during that time. The practical usefulness of this technique, which was also tried in two cases of imminent abortion, is discussed.