Adaptive and innate immune modulators of inflammation and autoimmunity.
Adaptive and innate immune modulators of inflammation and autoimmunity.
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炎症和自身免疫的适应性和先天免疫调节剂。
DOI：
10.1016/s1043-4666(15)00271-9
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发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Moudgil,KamalD
中科院分区：
文献类型：
--
作者：
Moudgil,KamalD
遗传和环境因素均导致炎症和自身免疫性疾病的发病机制。特定主要组织相容性复合体（MHC）等位基因与特定自身免疫性疾病易感性的关联是众所周知的，尽管这种联系的机制尚未完全阐明。此外，许多自身免疫性疾病的患病率在女性中远高于男性。目前，人们正在大力研究性激素、下丘脑-垂体-肾上腺（HPA）轴以及其他调节因素在性别二态性中的作用。在环境因素中，对肠道微生物群与免疫系统之间相互作用的新认识开辟了生物医学研究的新领域，为宿主与环境相互作用提供了新的视角。此外，除了特定的T辅助细胞亚群及其细胞因子产物外，清道夫受体、炎症小体、IL-1（例如IL-33、IL-37）和IL-12（例如IL-27、IL-35）家族的新型细胞因子以及脂肪细胞（脂肪因子）（例如瘦素、脂联素）产生的可溶性介质在炎症发病机制中的作用，自身免疫和代谢紊乱越来越受到人们的关注。在本期《免疫病理学与治疗中的细胞因子》第二卷中，权威专家分享了他们对上述细胞因子以及其他炎症和自身免疫调节因子的研究工作和观点。这里列出了第 2 卷 15 篇文章的概要。本期特刊第1卷近日出版，共14篇文章。
Both genetic and environmental factors contribute to the pathogenesis of inflammatory and autoimmune diseases. The association of specific major histocompatibility complex (MHC) alleles with susceptibility to particular autoimmune diseases is well known, although the mechanistic aspects of this link are not fully unraveled yet. Furthermore, the prevalence of many autoimmune diseases is much higher in females than in males. Intensive efforts are currently being directed to defining the role of sex hormones, the hypothalamic–pituitary–adrenal (HPA) axis, and other modifying factors in this sexual dimorphism. Among the environmental factors, emerging understanding of the interplay between the gut microbiota and the immune system has opened up a new frontier of biomedical research with a renewed perspective of host-environment interactions. In addition, besides specific T helper subsets and their cytokine products, the roles of the scavenger receptors, the inflammasome, the newer cytokines of the IL-1 (eg, IL-33, IL-37) and IL-12 (eg, IL-27, IL-35) families, and the soluble mediators produced by adipocytes (adipokines)(eg, leptin, adiponectin) in the pathogenesis of inflammation, autoimmunity, and metabolic disorders are increasingly being realized. In this special issue," Cytokines in Immune Pathology and Therapy," second volume, leading experts have shared their research work and perspectives on the above-mentioned cytokines and other modulators of inflammation and autoimmunity. An outline of 15 articles in volume 2 is presented here. Volume 1 of this special issue containing 14 articles was published recently.