How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.
How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.
复制标题
SAC 如何获得斧头：将动粒微管附件与纺锤体装配检查点信号集成。
DOI：
10.1080/19490992.2015.1090669
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Varma,Dileep
中科院分区：
文献类型：
--
作者：
Agarwal,Shivangi;Varma,Dileep
有丝分裂是指复制的染色体真正的分离。这一过程是通过染色体上的动粒附着到有丝分裂纺锤体的微管（MT）上来完成的。一旦实现了适当的附着，延迟后期过早开始的纺锤体组装检查点（SAC）需要沉默，以使细胞进行到后期和胞质分裂。因此，虽然在着丝粒未附着时必须保留SAC，但在着丝粒微管（kMT）附着后去除SAC组分是至关重要的。关于kMT附着如何触发SAC组分从动粒中去除或检查点蛋白如何反馈到附着机制的精确知识仍然是难以捉摸的。这篇综述旨在描述最近的进展，提供了一个深入了解的相互作用的分子事件，协调和调节SAC的活动，在细胞分裂过程中响应于kMT附件。
Mitosis entails the bona fide segregation of duplicated chromosomes. This process is accomplished by the attachment of kinetochores on chromosomes to microtubules (MTs) of the mitotic spindle. Once the appropriate attachment is achieved, the spindle assembly checkpoint (SAC) that delays the premature onset of anaphase needs to be silenced for the cell to proceed to anaphase and cytokinesis. Therefore, while it is imperative to preserve the SAC when kinetochores are unattached, it is of paramount importance that SAC components are removed post kinetochore microtubule (kMT) attachment. Precise knowledge of how kMT attachments trigger the removal of SAC components from kinetochores or how the checkpoint proteins feedback in to the attachment machinery remains elusive. This review aims to describe the recent advances that provide an insight into the interplay of molecular events that coordinate and regulate the SAC activity in response to kMT attachment during cell division.