Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals
Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals
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DOI：
10.1086/423176
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发表时间：
2004-09-01
影响因子：
11.8
通讯作者：
Cardellach, F
中科院分区：
文献类型：
--
作者：
Miró, O;López, S;Cardellach, F
为了研究HIV感染对线粒体DNA（mtDNA）含量和其他线粒体参数的影响，我们使用了25例无症状抗逆转录病毒初治人类免疫缺陷病毒（HIV）感染患者和25例健康对照者的外周血单核细胞（PBMC）。HIV感染者的mtDNA含量显著降低（降低23%; P
To investigate the effects of HIV infection on mitochondrial DNA (mtDNA) content and other mitochondrial parameters, we used peripheral blood mononuclear cells (PBMCs) from 25 asymptomatic antiretroviral-naive human immunodeficiency virus (HIV)-infected patients and from 25 healthy control subjects. HIV-infected patients had significant decreases in mtDNA content (decrease, 23%; P