Prenatal exposure to PBDEs and neurodevelopment.
Prenatal exposure to PBDEs and neurodevelopment.
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DOI：
10.1289/ehp.0901340
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发表时间：
2010-05
影响因子：
10.4
通讯作者：
Perera F
中科院分区：
文献类型：
--
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
多溴联苯醚(PBDEs)是一种应用广泛的阻燃化合物，具有持久性和生物累积性，已成为普遍存在的环境污染物。动物研究表明，产前接触多溴联苯醚可能会导致不利的神经发育影响。在2001年9月11日后开始的纵向队列中，包括在纽约曼哈顿下城三家医院之一分娩的329名母亲，我们在他们的孩子12-48岁和72个月大时检查了产前多溴二苯醚暴露和神经发育。我们分析了210份脐带血样本中选定的多溴联苯醚类似物，并评估了12-48和72个月大的儿童的神经发育影响；分别在12、24、36、48和72个月时评估了118、117、114、104和96名脐带血多溴二苯醚测定值。我们使用多元回归分析来评估个体多溴联苯醚同系物浓度与神经发育指数之间的关系。多溴联苯醚同系物47、99和100的脐血浓度中位数分别为11.2、3.2和1.4 ng/g脂肪。在调整了潜在的混杂因素后，在12-48个月和72个月时，BDEs浓度较高的儿童在智力和身体发育测试中的得分较低。12个月的精神运动发育指数(BDE-47)、24个月的精神发育指数(BDE-47、99和100)、36个月的MDI(BDE-100)、48个月的全量表和言语智商(BDE-47、99和100)、操作智商(BDE-100)和72个月的操作智商(BDE-100)具有显著的相关性。这项流行病学研究显示了与脐带血多溴二苯醚浓度有关的神经发育效应。在其他纵向研究中还需要证实。
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardant compounds that are persistent and bioaccumulative and therefore have become ubiquitous environment contaminants. Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects. In a longitudinal cohort initiated after 11 September 2001, including 329 mothers who delivered in one of three hospitals in lower Manhattan, New York, we examined prenatal PBDE exposure and neurodevelopment when their children were 12–48 and 72 months of age. We analyzed 210 cord blood specimens for selected PBDE congeners and assessed neurodevelopmental effects in the children at 12–48 and 72 months of age; 118, 117, 114, 104, and 96 children with available cord PBDE measurements were assessed at 12, 24, 36, 48, and 72 months, respectively. We used multivariate regression analyses to evaluate the associations between concentrations of individual PBDE congeners and neurodevelopmental indices. Median cord blood concentrations of PBDE congeners 47, 99, and 100 were 11.2, 3.2, and 1.4 ng/g lipid, respectively. After adjustment for potential confounders, children with higher concentrations of BDEs 47, 99, or 100 scored lower on tests of mental and physical development at 12–48 and 72 months. Associations were significant for 12-month Psychomotor Development Index (BDE-47), 24-month Mental Development Index (MDI) (BDE-47, 99, and 100), 36-month MDI (BDE-100), 48-month full-scale and verbal IQ (BDE-47, 99, and 100) and performance IQ (BDE-100), and 72-month performance IQ (BDE-100). This epidemiologic study demonstrates neurodevelopmental effects in relation to cord blood PBDE concentrations. Confirmation is needed in other longitudinal studies.