Changes in QT interval after switching to quetiapine in Japanese patients with schizophrenia.
Changes in QT interval after switching to quetiapine in Japanese patients with schizophrenia.
复制标题
日本精神分裂症患者改用喹硫平后 QT 间期的变化。
DOI：
10.1002/hup.2277
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Someya T.
中科院分区：
文献类型：
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作者：
Suzuki Y;Sugai T;Fukui N;Watanabe J;Ono S;Tsuneyama N;Saito M;Someya T.
目的：关于奎替卡松（QTP）相关QT间期延长的报道很少。我们研究了QT间期的变化后，从阿立哌唑（阿普），奥氮平（OLZ），或利培酮（RIS）QTP.MethodsTwenty与阿普，OLZ，或RIS治疗的受试者被纳入本研究。基线评估（包括QT间期和电解质）后，每例受试者将这三种药物转换为QTP。相同的参数进行了评估后切换到QTP.ResultsAll 20例患者已与阿普，OLZ，或RIS成功切换到QTP。转换后观察到总平均校正QT（QTc）间期显着增加（p= 0.014）。QTc间期变化程度的变异系数为1.66。平均QTc与阿普治疗后，QTP治疗显着增加（p= 0.004）。结论奎替鲁胺可能有更大的影响QTc间期比其他第二代抗精神病药物。然而，由于转换为QTP后QTc延长的程度存在相当大的变异性，因此需要进一步研究来阐明QTP对QTc间期的影响。版权所有© 2012约翰威利父子有限公司.
ObjectivesThere are few reports regarding quetiapine (QTP)‐related QT prolongation. We examined the change in QT interval after switching from aripiprazole (ARP), olanzapine (OLZ), or risperidone (RIS) to QTP.MethodsTwenty subjects treated with ARP, OLZ, or RIS were enrolled in the study. Following baseline assessments, which included QT interval and electrolytes, these three drugs were switched to QTP for each subject. The same parameters were evaluated following a switch to QTP.ResultsAll 20 patients who had been treated with ARP, OLZ, or RIS were successfully switched to QTP. Significant increases were observed in the total mean corrected QT (QTc) interval after switching (p= 0.014). The coefficient of variation for the extent of change in QTc interval was 1.66. The mean QTc with ARP treatment was significantly increased after QTP treatment (p= 0.004).ConclusionsQuetiapine might have a greater effect on QTc interval than other second‐generation antipsychotics. However, because there was a considerable variability in the extent of QTc prolongation after switch to QTP, further studies are required to clarify the effect of QTP on QTc interval. Copyright © 2012 John Wiley & Sons, Ltd.