New insight into the treatment of advanced differentiated thyroid cancer.
New insight into the treatment of advanced differentiated thyroid cancer.
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DOI：
10.1155/2012/437569
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发表时间：
2012
影响因子：
2.1
通讯作者：
Guerrero MA
中科院分区：
文献类型：
--
作者：
Safavi A;Vijayasekaran A;Guerrero MA
绝大多数分化型甲状腺癌（DTC）患者通过手术和放射性碘消融术成功治疗，但晚期病例的治疗令人沮丧且基本无效。常规细胞毒化疗的全身治疗对大多数晚期DTC患者基本无效。然而，对甲状腺癌遗传学和生物学基础的更好理解为创新治疗方式创造了机会，导致了几项临床试验。我们的目的是描绘有关DTC的生物学特性的最新知识，并描述与已证明临床有效性的新型靶向治疗相关的可用数据。
The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. Systemic treatment with conventional cytotoxic chemotherapy is basically ineffective in most patients with advanced DTC. However, a better understanding of the genetics and biologic basis of thyroid cancers has generated opportunities for innovative therapeutic modalities, resulting in several clinical trials. We aim to delineate the latest knowledge regarding the biologic characteristics of DTC and to describe the available data related to novel targeted therapies that have demonstrated clinical effectiveness.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.1200/jco.2007.15.9566
发表时间：
2008-10-10
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Cohen EE;Rosen LS;Vokes EE;Kies MS;Forastiere AA;Worden FP;Kane MA;Sherman E;Kim S;Bycott P;Tortorici M;Shalinsky DR;Liau KF;Cohen RB
通讯作者：
Cohen RB
DOI：
10.1158/1078-0432.ccr-10-0994
发表时间：
2010-11-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Carr LL;Mankoff DA;Goulart BH;Eaton KD;Capell PT;Kell EM;Bauman JE;Martins RG
通讯作者：
Martins RG
影响因子：
5.8
作者：
Ahmed, Merina;Barbachano, Yolanda;Nutting, Christopher M.
通讯作者：
Nutting, Christopher M.
影响因子：
6.6
作者：
Ain, Kenneth B.;Lee, Charles;Williams, Kevin D.
通讯作者：
Williams, Kevin D.