Ga(III)-catalyzed cycloisomerization strategy for the synthesis of icetexane diterpenoids:: Total synthesis of (±)-salviasperanol
Ga(III)-catalyzed cycloisomerization strategy for the synthesis of icetexane diterpenoids:: Total synthesis of (±)-salviasperanol
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DOI：
10.1021/ol061037c
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发表时间：
2006-06-22
期刊：
影响因子：
5.2
通讯作者：
Sarpong, Richmond
中科院分区：
文献类型：
--
作者：
Simmons, Eric M.;Sarpong, Richmond
本文提出了一种以氯化镓为催化剂，通过炔基吲哚的环异构化合成二十碳六烷类天然产物三环核的一般方法。这一策略提供了天然产物丹参的有效合成，并为获得该二萜类化合物家族的其他成员奠定了基础。
A general approach to the tricyclic core of the icetexane natural products via the cycloisomerization of alkynyl indenes using GaCl3 is presented. This strategy provides an efficient synthesis of the natural product salviasperanol and sets the stage for access to other members of this family of diterpenoids.