Hepatic lesion detection and characterization:: Value of nonenhanced MR imaging, superparamagnetic iron oxide-enhanced MR imaging, and spiral CT-ROC analysis
Hepatic lesion detection and characterization:: Value of nonenhanced MR imaging, superparamagnetic iron oxide-enhanced MR imaging, and spiral CT-ROC analysis
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DOI：
10.1148/radiology.217.1.r00oc31152
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发表时间：
2000-10-01
期刊：
影响因子：
19.7
通讯作者：
Saini, S
中科院分区：
文献类型：
--
作者：
Reimer, P;Jähnke, N;Saini, S
目得：确定非增强、超顺磁性氧化铁（SPIO）增强或非增强和SPIO增强MR成像与对比增强螺旋计算机断层扫描（CT）相结合检测和表征肝脏局灶性病变的准确性。材料和方法：螺旋CT和T2加权SPIO增强对35例肝脏恶性病变患者术前2周内进行了磁共振成像检查。仅考虑有组织病理学证据的恶性病变。向5名阅片人提供了875张有局灶性病变的图像和800张无局灶性病变的图像，要求阅片人使用5点置信度量表评估病变的存在和表征。结果：非增强和SPIO增强图像一起和SPIO增强图像单独产生的病变检测的最佳性能。所有成像技术在病变表征（良性与恶性）方面无差异。联合方法导致ROC曲线下面积更大（A（z）= 0.9062）和准确性（百分之八十五点三）与SPIO增强MRI（A（z）= 0.8667;准确率73.1%）比较，P < 0.02。SPIO增强T2加权成像比非增强T1加权和T2加权成像更准确，增强螺旋CT对肝脏局灶性病变的诊断价值。联合分析平扫和SPIO增强图像比单独回顾SPIO增强图像更准确地描述肝脏局灶性病变的特征。
PURPOSE: To determine the accuracy for detection and characterization of focal hepatic lesions of nonenhanced, superparamagnetic iron oxide (SPIO)-enhanced, or a combination of nonenhanced and SPIO-enhanced MR imaging and contrast-enhanced spiral computed tomography (CT).MATERIALS AND METHODS: Spiral CT and T2-weighted SPIO-enhanced (ferucarbotran-enhanced) MR imaging were performed in 35 patients within 2 weeks before surgery for malignant hepatic lesions. Only malignant lesions with histopathologic proof were considered. A total of 875 images with and 800 images without focal lesions were presented to five readers, who were asked to assess the presence and characterization of lesions by using a five-point confidence scale. Receiver operating characteristic analysis was performed.RESULTS: Nonenhanced and SPIO-enhanced images together and SPIO-enhanced images alone yielded the best performance for lesion detection. No differences were found among all imaging techniques with regard to lesion characterization (benign vs malignant). The combined approach resulted in larger area under the ROC curve (A(z) = 0.9062) and accuracy (85.3%) (P < 0.02), as compared with SPIO-enhanced MR imaging (A(z) = 0.8667; accuracy, 73.1%).CONCLUSION: SPIO-enhanced T2-weighted MR imaging was more accurate than nonenhanced T1-weighted and T2-weighted MR imaging and contrast-enhanced spiral CT for the detection of focal hepatic lesions. The combined analysis of nonenhanced and SPIO-enhanced images was more accurate in the characterization of focal hepatic lesions than was review of SPIO-enhanced images alone.