Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan
Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan
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DOI：
10.1016/s1474-4422(15)00050-2
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发表时间：
2015-11-01
期刊：
影响因子：
48
通讯作者：
Murphy, Declan G. M.
中科院分区：
文献类型：
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作者：
Ecker, Christine;Bookheimer, Susan Y.;Murphy, Declan G. M.
在过去的十年中，体内MRI研究为自闭症谱系障碍（ASD）的神经基质提供了许多宝贵的见解，现在已知ASD与大脑解剖学，功能和连接的神经发育变化有关。ASD病理学的这些系统水平特征似乎在整个人类寿命中有差异地发展，因此ASD儿童中发生的皮质异常与生命其他阶段的异常不同。因此，对ASD患者大脑的研究提出了特殊的方法学挑战，必须解决这些挑战，以便能够比较不同研究的结果。新的分析方法也正在开发中，以促进研究结果转化为临床环境。在未来，人类神经影像学研究提供的见解可能有助于ASD和其他神经发育障碍的生物标志物开发，以及诊断和治疗的新方法。
Over the past decade, in-vivo MRI studies have provided many invaluable insights into the neural substrates underlying autism spectrum disorder (ASD), which is now known to be associated with neurodevelopmental variations in brain anatomy, functioning, and connectivity. These systems-level features of ASD pathology seem to develop differentially across the human lifespan so that the cortical abnormalities that occur in children with ASD differ from those noted at other stages of life. Thus, investigation of the brain in ASD poses particular methodological challenges, which must be addressed to enable the comparison of results across studies. Novel analytical approaches are also being developed to facilitate the translation of findings from the research to the clinical setting. In the future, the insights provided by human neuroimaging studies could contribute to biomarker development for ASD and other neurodevelopmental disorders, and to new approaches to diagnosis and treatment.