THE FREQUENCY OF A NORWALK-LIKE PATTERN OF ILLNESS IN OUTBREAKS OF ACUTE GASTROENTERITIS
THE FREQUENCY OF A NORWALK-LIKE PATTERN OF ILLNESS IN OUTBREAKS OF ACUTE GASTROENTERITIS
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DOI：
10.2105/ajph.72.12.1329
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发表时间：
1982-01-01
影响因子：
12.7
通讯作者：
GARY, GW
中科院分区：
文献类型：
--
作者：
KAPLAN, JE;FELDMAN, R;GARY, GW
回顾了642例急性胃肠炎暴发的记录，以确定临床和流行病学上与诺瓦克样病毒感染一致的暴发比例。以粪便培养阴性为标准，细菌病原体，平均（或中位数）病程12-60小时，呕吐。50%的病例，以及（如果知道的话）24-48小时的平均（或中位数）潜伏期，23%的水源性暴发，4%的食源性暴发，以及分别发生在养老院、夏令营和游轮上的67%、60%和28%的暴发符合诺瓦克样模式的标准。在54例满足诺瓦克样型标准的暴发中，对14例进行了病毒病原学调查。其中10例（71%）产生诺瓦克样病毒感染的血清学证据。诺瓦克样病毒可能是急性胃肠炎暴发的重要原因。在临床和流行病学上与诺瓦克样病毒感染一致的暴发中，诺瓦克病毒抗体的调查可能产生有用的诊断结果。
Records of 642 outbreaks of acute gastroenteritis were reviewed to determine the proportion of outbreaks that were clinically and epidemiologically consistent with Norwalk-like virus infection. Using as criteria stool cultures negative for bacterial pathogens, mean (or median) duration of illness 12-60 h, vomiting in .gtoreq. 50% of cases, and, if known, mean (or median) incubation period of 24-48 h, 23% of waterborne outbreaks, 4% of foodborne outbreaks and 67%, 60%, and 28% of outbreaks in nursing homes, in summer camps and on cruise ships, respectively, were found to satify the criteria for Norwalk-like pattern. Of 54 outbreaks that satisfied the criteria for Norwalk-like pattern, 14 were investigated for virus etiology. Ten of these (71%) yielded serologic evidence of Norwalk-like virus infection. Norwalk-like viruses are probably an important cause of outbreaks of acute gastroenteritis. Investigation for Norwalk virus antibody in outbreaks that are clinically and epidemiologically consistent with Norwalk-like virus infection is likely to yield diagnostically useful results.