GASTROINTESTINAL SYMPTOMS IN PARKINSON DISEASE - 18-MONTH FOLLOW-UP-STUDY
GASTROINTESTINAL SYMPTOMS IN PARKINSON DISEASE - 18-MONTH FOLLOW-UP-STUDY
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DOI：
10.1002/mds.870080115
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发表时间：
1993-01-01
影响因子：
8.6
通讯作者：
PFEIFFER, RF
中科院分区：
文献类型：
--
作者：
EDWARDS, L;QUIGLEY, EMM;PFEIFFER, RF
在最近的一项研究中，我们将异常流涎、吞咽困难、恶心、便秘和排便功能障碍确定为与帕金森病（PD）相关的胃肠道（GI）症状，并描述了其与PD严重程度和治疗的关系。在这项研究中，我们重新评估了这些症状及其与PD参数的关系18个月后。66%的原始参与者做出了回应。在18个月内，68%的最初未经治疗的PD受试者开始抗PD治疗。异常流涎、吞咽困难、恶心、便秘和排便功能障碍再次被确定为PD中更常见的GI症状。并发症的严重程度和频率均增加。GI症状评分和PD功能障碍参数的比较未能显示18个月期间GI炎症或PD功能障碍的显著进展或新GI症状的发展。本研究验证了我们的胃肠道功能障碍评估系统，并确认异常流涎，吞咽困难，恶心，便秘和排便功能是真正与PD相关的胃肠道症状。PD与其相关GI症状之间的直接关系再次得到支持。
In a recent study we identified abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction as those gastrointestinal (GI) symptoms associated with Parkinson disease (PD) and characterized their relationship to PD severity and therapy. In this study, we re-evaluated these symptoms and their relationship to parameters of PD 18 months later. Sixty-six percent of the original participants responded. Over the 18 months, 68% of originally untreated PD subjects commenced anti-PD therapy. Abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction were again identified as those GI symptoms more common in PD. Constipation increased both in severity and frequency. Comparison of GI symptom scores and parameters of PD dysfunction failed to reveal significant progression of either GI symptomatology or PD dysfunction, or the development of new GI symptoms over the 18-month period. This study validates our GI dysfunction assessment system and confirms abnormal salivation, dysphagia, nausea, constipation, and defecatory function as those GI symptoms truly associated with PD. A direct relationship between PD and its related GI symptoms is again supported.