IMMUNOHISTOCHEMICAL LOCALIZATION OF TYPE-I, TYPE-II, AND TYPE-III COLLAGENS IN THE OSSIFIED POSTERIOR LONGITUDINAL LIGAMENT OF THE HUMAN CERVICAL-SPINE
IMMUNOHISTOCHEMICAL LOCALIZATION OF TYPE-I, TYPE-II, AND TYPE-III COLLAGENS IN THE OSSIFIED POSTERIOR LONGITUDINAL LIGAMENT OF THE HUMAN CERVICAL-SPINE
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DOI：
10.1007/bf02405024
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发表时间：
1983-01-01
影响因子：
4.2
通讯作者：
NAGAI, Y
中科院分区：
文献类型：
--
作者：
YASUI, N;ONO, K;NAGAI, Y
应用型特异性抗胶原抗体对颈椎骨化后纵韧带内I、II、III型胶原的免疫组织化学定位进行了研究。与含有I型和III型胶原的正常韧带不同，由板层骨组成的骨化基质只含有I型胶原，除了内壁有III型胶原的哈弗斯管。在前骨化韧带的过渡区，III型和I型都存在。II型胶原存在于韧带的增生性基质中，由II型胶原包围的软骨样细胞沿邻近前骨化区的未骨化韧带排列。对骨化过程中基质转变的可能机制进行了讨论。
Immunohistochemical localization of types I, II and III collagen in the ossified posterior longitudinal ligament of the cervical spine was studied using type-specific anticollagen antibodies. In contrast to the normal ligament which contains both types I and III collagens, the ossified matrix, composed of lamellar bone, contains only type I collagen, except for Haversian canals where type III is located in the inner wall. In the transitional region of preossifying ligaments, types III and I are both present. Type II collagen is present in the hyperplastic matrix of the ligament and cartilage-like cells surrounded by type II collagen are aligned along nonossified ligaments adjacent to the preossifying region. A possible mechanism to matrix transition during the ossification process is given attention.