Cytotoxic anthraquinone dimers from Melandrium firmum
Cytotoxic anthraquinone dimers from Melandrium firmum
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DOI：
10.1007/s12272-014-0360-2
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发表时间：
2014-02
影响因子：
6.7
通讯作者：
Changhao Zhang;Dalei Yao;Cheng-Shen Li;Jie Luo;Mei Jin;M. Zheng;Z. Lin;Tie-Feng Jin;Gao Li
中科院分区：
文献类型：
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作者：
Changhao Zhang;Dalei Yao;Cheng-Shen Li;Jie Luo;Mei Jin;M. Zheng;Z. Lin;Tie-Feng Jin;Gao Li
从Melandrium Firmum Rohrbach 的地上部分分离出两种新的蒽醌二聚体，melrubiellin A (1) 和melrubiellin B (2)，以及七种已知化合物(3-9)。通过光谱分析，包括一维和二维核磁共振（COSY、HMQC、HMBC 和 NOESY）实验，阐明了这些化合物的结构。化合物 1 和 2 对 HeLa、NCI-H460、Hep G2、Hep 3B 和 MKN-28 细胞系表现出显着的细胞毒性，IC50 值范围为 5.26 至 81.16 μM。
Two new anthraquinone dimers, melrubiellin A (1) and melrubiellin B (2), were isolated from the aerial part ofMelandrium firmumRohrbach, along with seven known compounds (3–9). The structures of these compounds were elucidated by spectral analyses, including 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. Compound1and2exhibited significant cytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3B and MKN-28 cell lines with IC50values ranging from 5.26 to 81.16 μM.